Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 3/20 | 0.38 |
| ▸ | MAPK8 | P45983 | 4/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | TOP2A | P11388 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | TOP2B | Q02880 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.32 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11275888 | 0.88 | PIK3CG (0.41) | PIK3CGMAPK8KDM4EALDH1A1LMNA | |
| SCHEMBL9805938 | 0.86 | KDM4E (0.50) | PIK3CGKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL7851039 | 0.80 | PIK3CG (0.36) | PIK3CGKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL6668440 | 0.79 | KDM4E (0.36) | PIK3CGMAPK8KDM4EALDH1A1LMNA | |
| SCHEMBL7851048 | 0.77 | PIK3CG (0.33) | PIK3CGKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL7850855 | 0.77 | PIK3CG (0.32) | PIK3CGKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL10376893 | 0.76 | KDM4E (0.55) | PIK3CGKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL10378390 | 0.76 | KDM4E (0.55) | PIK3CGKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL10377584 | 0.76 | KDM4E (0.55) | PIK3CGKDM4EALDH1A1LMNAHPGD | |
| SCHEMBL7851241 | 0.75 | PIK3CG (0.33) | PIK3CGKDM4EALDH1A1LMNAHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049355-B1 | 7-Amino-1-cyclopropyl-4-oxo-1,4-dihydro-(naphthyridine or quinoline)-3-carboxylic acids, process for their preparation and pharmaceutical compositions containing them | BAYER AG (DE) | 1984-10-10 | — | — | EP | disclosed |
| EP-0049355-A1 | 7-Amino-1-cyclopropyl-4-oxo-1,4-dihydro-(naphthyridine or quinoline)-3-carboxylic acids, process for their preparation and pharmaceutical compositions containing them | BAYER AG (DE) | 1982-04-14 | — | — | EP | disclosed |