Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.48 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.48 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL571146 | 0.82 | ALDH1A1 (0.66) | ALDH1A1LMNARAB9ANPC1HDAC3 | |
| SCHEMBL11586796 | 0.80 | ALDH1A1 (0.50) | ALDH1A1LMNARAB9ANPC1HDAC3 | |
| SCHEMBL24697978 | 0.79 | ALDH1A1 (0.66) | ALDH1A1LMNARAB9ANPC1HDAC3 | |
| SCHEMBL6469838 | 0.78 | ALDH1A1 (0.59) | ALDH1A1LMNARAB9ANPC1HDAC3 | |
| SCHEMBL27271335 | 0.76 | ALDH1A1 (0.72) | ALDH1A1LMNARAB9ANPC1HDAC3 | |
| SCHEMBL10247697 | 0.76 | NPC1 (0.66) | ALDH1A1RAB9ANPC1HDAC3HDAC4 | |
| SCHEMBL1932191 | 0.76 | ALDH1A1 (1.00) | ALDH1A1LMNARAB9ANPC1HDAC3 | |
| SCHEMBL3959624 | 0.74 | ALDH1A1 (0.75) | ALDH1A1LMNARAB9ANPC1HDAC3 | |
| SCHEMBL27271332 | 0.73 | ALDH1A1 (0.68) | ALDH1A1LMNARAB9ANPC1HDAC3 | |
| SCHEMBL8160357 | 0.73 | ALDH1A1 (0.72) | ALDH1A1LMNARAB9ANPC1HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101534904-B | BCL inhibitors for the treatment of platelet excess | ABBOTT LAB | 2013-11-06 | — | — | CN | disclosed |
| EP-2279174-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009143246-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-11-26 | — | — | WO | disclosed |
| EP-1685119-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | Abbott Laboratories (US) | 2006-08-02 | — | — | EP | disclosed |
| WO-2005049593-A2 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-06-02 | — | — | WO | disclosed |
| WO-2005049594-A1 | N-ACYLSULFONAMIDE APOPTOSIS PROMOTERS | ABBOTT LABORATORIES (US) | 2005-06-02 | — | — | WO | disclosed |