Vadimezan

Vadimezan

SCHEMBL111183

Cc1ccc2c(=O)c3cccc(CC(=O)O)c3oc2c1C

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Full drug profile on Sugi Atlas →

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
STING1 Q86WV6 2/20 1.00
GLA P06280 1/20 1.00
SMN1; SMN2 Q16637 2/20 0.55
KDM4E B2RXH2 1/20 0.48
MCL1 Q07820 1/20 0.46
TDP1 Q9NUW8 1/20 0.42
PON1 P27169 1/20 0.42
NQO1 P15559 1/20 0.42
NPC1 O15118 2/20 0.41
RAB9A P51151 2/20 0.41
MEN1 O00255 2/20 0.41
KMT2A Q03164 2/20 0.41
DUSP3 P51452 1/20 0.40
PTPN5 P54829 1/20 0.40
PTPN11 Q06124 1/20 0.40
CTDSP1 Q9GZU7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Vadimezan SCHEMBL29363732 1.00 STING1 (1.00) STING1GLASMN1; SMN2KDM4EMCL1
Vadimezan SCHEMBL29356696 1.00 STING1 (1.00) STING1GLASMN1; SMN2KDM4EMCL1
Vadimezan SCHEMBL4282930 0.99 STING1 (0.97) STING1GLASMN1; SMN2KDM4EMCL1
Vadimezan SCHEMBL4282923 0.99 STING1 (0.97) STING1GLASMN1; SMN2KDM4EMCL1
SCHEMBL13025119 0.89 GLA (0.81) STING1GLASMN1; SMN2KDM4EMCL1
SCHEMBL19209663 0.88 GLA (0.79) STING1GLASMN1; SMN2KDM4EMCL1
SCHEMBL20762991 0.88 STING1 (0.79) STING1GLASMN1; SMN2KDM4ETDP1
SCHEMBL20845573 0.88 GLA (0.79) STING1GLASMN1; SMN2KDM4EMCL1
SCHEMBL8280464 0.88 GLA (0.79) STING1GLASMN1; SMN2KDM4EMCL1
SCHEMBL9381286 0.87 STING1 (0.78) STING1GLASMN1; SMN2KDM4EMCL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Appears in 2669 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12617812-B2 Platinum(IV) complexes, methods of manufacture, compositions containing, and methods of use thereof CITY UNIVERSITY OF HONG KONG (HK) 2026-05-05 US claimed
US-12397047-B2 Bacteria-derived vesicles and uses thereof EXOCURE SWEDEN AB (SE) 2025-08-26 US claimed
US-20250186486-A1 POTENTIATION OF DURABLE ANTITUMOR IMMUNITY BY MULTIFACTORIAL IMMUNE MODULATION BAYLOR COLLEGE OF MEDICINE (US) 2025-06-12 US claimed
US-20250186623-A1 EXPRESSION SYSTEM FOR THE TREATMENT OF CANCER FUNDACION PARA LA INVESTIGACION MEDICA APLICADA (ES) 2025-06-12 US claimed
US-20250188143-A1 COMBINED GENE AND RADIO THERAPY FOR THE TREATMENT OF CANCER FUNDACION PARA LA INVESTIGACION MEDICA APLICADA (ES) 2025-06-12 US claimed
US-20250127790-A1 COMBINATION THERAPY USING VPS34 INHIBITORS DECIPHERA PHARMACEUTICALS, LLC 2025-04-24 US claimed
WO-2025080869-A1 PANCREATIC CANCER IMMUNOTHERAPY USING CATIONIC LIPID AND POLYMER NANOCARRIERS FOR CO-DELIVERY OF KRAS NEOANTIGENS AND STING AND/OR OTHER IMMUNOMODULATORS TO BOOST THE CANCER IMMUNITY CYCLE AND TREAT LIVER METASTASIS THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2025-04-17 WO claimed
WO-2025076039-A1 CHLAMYDIAL PROTEASE-LIKE ACTIVITY FACTOR AND ADJUVANT COMPOSITIONS AND USES THEREOF THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) 2025-04-10 WO claimed
WO-2025076210-A1 CHLAMYDIA VACCINE COMPOSITIONS VAXCYTE, INC. (US) 2025-04-10 WO claimed
EP-4489795-A1 EXPRESSION SYSTEM FOR THE TREATMENT OF CANCER Fundación para la Investigación Médica Aplicada (ES) 2025-01-15 EP claimed
EP-1189611-A4 CANCER THERAPY CANCER RES VENTURES LTD (GB) 2003-05-02 EP claimed
US-20030003092-A1 Cancer therapy KRISSANSEN GEOFFREY W (NZ) 2003-01-02 US claimed
US-6495585-B2 Method for treating hyperproliferative tissue in a mammal HEALTH RESEARCH, INC. 2002-12-17 US claimed
US-20020128303-A1 Method for treating hyperproliferative tissue in a mammal NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2002-09-12 US claimed
EP-1238666-A2 Use of xanthenone-4-acetic acid in the manufacture of a medicament in the treatment of hyperproliferative disorders HEALTH RESEARCH, INC. (US) 2002-09-11 EP claimed
EP-1189611-A1 CANCER THERAPY Cancer Research Ventures Limited (GB) 2002-03-27 EP claimed
WO-2002009700-A1 CANCER TREATMENT BY COMBINATION THERAPY CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2002-02-07 WO claimed
US-20010027210-A1 Combination therapy for cancer CANCER RESEARCH TECHNOLOGY LIMITED (GB) 2001-10-04 US claimed
WO-2000076497-A1 CANCER THERAPY CANCER RESEARCH VENTURES LIMITED (GB) 2000-12-21 WO claimed
US-5281620-A Alkyl substituted xanthenone-4-acetic acid CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) 1994-01-25 US claimed