Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | PDE3A | Q14432 | 11/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 8/20 | 0.39 |
| ▸ | PDE4A | P27815 | 7/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 7/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 7/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.35 |
| ▸ | NPY1R | P25929 | 1/20 | 0.35 |
| ▸ | NPY2R | P49146 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296033 | 0.76 | MAPT (0.45) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL7983325 | 0.75 | SMN1; SMN2 (0.64) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL2986344 | 0.75 | KCNH2 (0.52) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11371397 | 0.72 | SMN1; SMN2 (0.38) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL7284601 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL2986346 | 0.71 | SMN1; SMN2 (0.47) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11370899 | 0.70 | PTGER4 (0.44) | SMN1; SMN2LMNARAB9AKDM4EL3MBTL1 | |
| SCHEMBL7300917 | 0.69 | POLB (0.48) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL9184755 | 0.68 | PDE3B (0.57) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11571230 | 0.67 | SMN1; SMN2 (0.47) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0116853-A1 | Pyridazinones, processes for preparing them, therapeutical compositions containing these compounds and their use | BASF Aktiengesellschaft (DE) | 1984-08-29 | — | — | EP | disclosed |