Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 11/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 6/20 | 0.41 |
| ▸ | PDE4A | P27815 | 5/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 5/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.37 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.37 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7298081 | 0.75 | SMN1; SMN2 (0.50) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL22284852 | 0.75 | PDE3B (0.48) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL22284833 | 0.75 | SMN1; SMN2 (0.47) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11572086 | 0.74 | SMN1; SMN2 (0.45) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL9686080 | 0.74 | SMN1; SMN2 (0.49) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL22284822 | 0.73 | PDE3B (0.46) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL20702777 | 0.73 | PDE3B (0.52) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL11737729 | 0.72 | PDE3A (0.48) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL7284601 | 0.72 | SMN1; SMN2 (0.46) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A | |
| SCHEMBL10755676 | 0.72 | PDE3B (0.58) | SMN1; SMN2PDE3APDE3BPDE4BPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359439-A1 | Substituted pyridazinones | ORION-YHTYMÄ OY (FI) | 1990-03-21 | — | — | EP | disclosed |