Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 12/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.52 |
| ▸ | GALR3 | O60755 | 3/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | SLFN12 | Q8IYM2 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11159409 | 0.86 | PDE3B (0.67) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11164631 | 0.86 | PDE3B (0.67) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11161927 | 0.86 | PDE3B (0.76) | PDE3BPDE3AMAPTSMN1; SMN2GALR3 | |
| SCHEMBL11176102 | 0.86 | PDE3B (0.72) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11159048 | 0.83 | PDE3B (0.63) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11167091 | 0.82 | PDE3B (0.60) | PDE3BPDE3AMAPTSMN1; SMN2GALR3 | |
| SCHEMBL11160996 | 0.81 | PDE3B (0.78) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11164767 | 0.80 | PDE3B (0.58) | PDE3BPDE3AMAPTSMN1; SMN2GALR3 | |
| SCHEMBL11160053 | 0.79 | PDE3B (0.63) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11169119 | 0.79 | PDE3B (0.63) | PDE3BPDE3AMAPTSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0042513-B1 | DIHYDROPYRIDAZINONES, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS | BASF Aktiengesellschaft (DE) | 1984-08-08 | — | — | EP | disclosed |
| US-4415571-A | HYPOTENSIVE AGENTS; THROMBOSIS; ANTICOAGULANTS; CARDIOVASCULAR DISORDDERS | BASF AKTIENGESELLSCHAFT (DE) | 1983-11-15 | — | — | US | disclosed |
| EP-0042513-A1 | Dihydropyridazinones, processes for their preparation and pharmaceutical compositions containing these compounds | BASF Aktiengesellschaft (DE) | 1981-12-30 | — | — | EP | disclosed |