Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 18/20 | 0.73 |
| ▸ | BCL2L1 | Q07817 | 16/20 | 0.73 |
| ▸ | BCL2L2 | Q92843 | 4/20 | 0.73 |
| ▸ | MDM4 | O15151 | 1/20 | 0.55 |
| ▸ | BCL2L11 | O43521 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | BID | P55957 | 1/20 | 0.55 |
| ▸ | BAX | Q07812 | 1/20 | 0.55 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.55 |
| ▸ | ASPH | Q12797 | 1/20 | 0.55 |
| ▸ | BECN1 | Q14457 | 1/20 | 0.55 |
| ▸ | BAK1 | Q16611 | 1/20 | 0.55 |
| ▸ | BAD | Q92934 | 1/20 | 0.55 |
| ▸ | BBC3 | Q9BXH1 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1112261 | 1.00 | BCL2 (0.73) | BCL2BCL2L1BCL2L2MDM4BCL2L11 | |
| SCHEMBL1677384 | 0.95 | BCL2 (0.80) | BCL2BCL2L1BCL2L2MDM4BCL2L11 | |
| SCHEMBL1677385 | 0.95 | BCL2 (0.80) | BCL2BCL2L1BCL2L2MDM4BCL2L11 | |
| SCHEMBL1112346 | 0.91 | BCL2 (0.73) | BCL2BCL2L1BCL2L2MCL1 | |
| SCHEMBL1112446 | 0.91 | BCL2 (0.64) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL1112349 | 0.91 | BCL2 (0.73) | BCL2BCL2L1BCL2L2MCL1 | |
| SCHEMBL1112451 | 0.91 | BCL2 (0.64) | BCL2BCL2L1BCL2L2 | |
| SCHEMBL1111816 | 0.89 | BCL2 (0.70) | BCL2BCL2L1BCL2L2MDM4BCL2L11 | |
| SCHEMBL1111811 | 0.89 | BCL2 (0.70) | BCL2BCL2L1BCL2L2MDM4BCL2L11 | |
| SCHEMBL1112405 | 0.88 | BCL2 (0.90) | BCL2BCL2L1BCL2L2MDM4BCL2L11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279174-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009143246-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-11-26 | — | — | WO | disclosed |