Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 19/20 | 0.73 |
| ▸ | BCL2L1 | Q07817 | 16/20 | 0.73 |
| ▸ | BCL2L2 | Q92843 | 9/20 | 0.60 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1112346 | 1.00 | BCL2 (0.73) | BCL2BCL2L1BCL2L2MCL1 | |
| SCHEMBL1677491 | 0.95 | BCL2 (0.80) | BCL2BCL2L1BCL2L2MCL1 | |
| SCHEMBL1677493 | 0.95 | BCL2 (0.80) | BCL2BCL2L1BCL2L2MCL1 | |
| SCHEMBL1112261 | 0.91 | BCL2 (0.73) | BCL2BCL2L1BCL2L2MCL1 | |
| SCHEMBL1112258 | 0.91 | BCL2 (0.73) | BCL2BCL2L1BCL2L2MCL1 | |
| SCHEMBL1111857 | 0.89 | BCL2 (0.90) | BCL2BCL2L1BCL2L2MCL1 | |
| SCHEMBL1111860 | 0.89 | BCL2 (0.90) | BCL2BCL2L1BCL2L2MCL1 | |
| SCHEMBL1677562 | 0.87 | BCL2 (0.75) | BCL2BCL2L1BCL2L2MCL1 | |
| SCHEMBL1677563 | 0.87 | BCL2 (0.75) | BCL2BCL2L1BCL2L2MCL1 | |
| SCHEMBL1112265 | 0.87 | BCL2 (0.89) | BCL2BCL2L1BCL2L2MCL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279174-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009143246-A2 | ARYLSULFONAMIDE COMPOUNDS, COMPOSITIONS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-11-26 | — | — | WO | disclosed |