Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 2/20 | 0.67 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 5/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.44 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10725655 | 1.00 | LMNA (0.67) | LMNACYP1A2KDM4EHPGDNPC1 | |
| SCHEMBL9394256 | 0.76 | NPC1 (1.00) | LMNACYP1A2KDM4ENPC1RAB9A | |
| SCHEMBL229328 | 0.76 | NPC1 (1.00) | LMNACYP1A2KDM4ENPC1RAB9A | |
| SCHEMBL31560044 | 0.76 | NPC1 (1.00) | LMNACYP1A2KDM4ENPC1RAB9A | |
| SCHEMBL229329 | 0.76 | NPC1 (1.00) | LMNACYP1A2KDM4ENPC1RAB9A | |
| SCHEMBL10986314 | 0.75 | CYP1A2 (0.72) | LMNACYP1A2KDM4EHPGDNPC1 | |
| SCHEMBL10767136 | 0.71 | PTGS1 (1.00) | LMNACYP1A2KDM4EHPGDNPC1 | |
| SCHEMBL10763055 | 0.71 | PTGS1 (0.62) | LMNACYP1A2KDM4EHPGDNPC1 | |
| SCHEMBL10767140 | 0.71 | PTGS1 (1.00) | LMNACYP1A2KDM4EHPGDNPC1 | |
| SCHEMBL10763057 | 0.71 | PTGS1 (0.62) | LMNACYP1A2KDM4EHPGDNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0150463-A1 | Substituted 4.5-dihydro-6-vinyl-3(2H)-pyridazinones and 6-vinyl-3(2H)-pyridazinones and process for producing the same | A. Nattermann & Cie. GmbH (DE) | 1985-08-07 | — | — | EP | disclosed |