Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DNM1 | Q05193 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.53 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11135834 | 0.98 | DNM1 (0.62) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL11136129 | 0.98 | DNM1 (0.62) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL11136184 | 0.98 | DNM1 (0.62) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL11135512 | 0.98 | DNM1 (0.62) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL11136577 | 0.96 | DNM1 (0.54) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL11135842 | 0.93 | DNM1 (0.50) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL11136107 | 0.89 | DNM1 (0.69) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL11131463 | 0.87 | DNM1 (0.72) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL11134822 | 0.87 | DNM1 (0.72) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 | |
| Bromide SCHEMBL11133019 | 0.87 | DNM1 (0.72) | DNM1MEN1KMT2AMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4395410-A | Quaternary ammonium antiarrhythmic drugs | ELI LILLY AND COMPANY (US) | 1983-07-26 | — | — | US | disclosed |
| EP-0002604-B1 | QUATERNARY AMMONIUM SALTS, AND THEIR FORMULATIONS AND PREPARATION | ELI LILLY AND COMPANY (US) | 1983-05-04 | — | — | EP | disclosed |
| US-4289787-A | PROLONG ACTION POTENTIAL OF CARDIAC TISSUE | ELI LILLY AND COMPANY (US) | 1981-09-15 | — | — | US | disclosed |
| EP-0002604-A1 | Quaternary ammonium salts, and their formulations and preparation | ELI LILLY AND COMPANY (US) | 1979-06-27 | — | — | EP | disclosed |