Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 18/20 | 0.55 |
| ▸ | MTOR | P42345 | 8/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 6/20 | 0.53 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.53 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.44 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.43 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1114171 | 0.95 | PIK3CA (0.56) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL336204 | 0.86 | PIK3CA (0.67) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL1113658 | 0.85 | PIK3CA (0.57) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL1114137 | 0.83 | PIK3CA (0.59) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL337181 | 0.82 | PIK3CA (0.62) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL27932585 | 0.82 | PIK3CA (0.56) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL1114084 | 0.82 | PIK3CA (0.61) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL1114200 | 0.81 | PIK3CA (0.55) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL2877565 | 0.80 | PIK3CA (0.60) | PIK3CAMTORPIK3CGPIK3CDHDAC1 | |
| SCHEMBL1113697 | 0.80 | PIK3CA (0.59) | PIK3CAMTORPIK3CGPIK3CDHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279188-B1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH INC (US) | 2015-01-28 | — | — | EP | claimed |
| EP-2279188-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009146406-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-12-03 | — | — | WO | disclosed |