Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.55 |
| ▸ | MTOR | P42345 | 10/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 4/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.44 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.41 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1114195 | 0.84 | PIK3CA (0.59) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL27813632 | 0.82 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL1113665 | 0.81 | PIK3CA (0.55) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL1114289 | 0.80 | PIK3CA (0.63) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL1114171 | 0.79 | PIK3CA (0.56) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL1114010 | 0.77 | PIK3CA (0.59) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL1114001 | 0.77 | PIK3CA (0.72) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL16411842 | 0.73 | PIK3CA (0.63) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL1114089 | 0.72 | PIK3CA (0.70) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 | |
| SCHEMBL1114139 | 0.72 | PIK3CA (1.00) | PIK3CAMTORPIK3CDPIK3CGPIK3R1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279188-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | claimed |
| WO-2009146406-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-12-03 | — | — | WO | claimed |