SCHEMBL1114128

SCHEMBL1114128

NC(=O)c1nc(-c2ccc(OC(F)(F)F)cc2)no1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SCN10A Q9Y5Y9 1/20 0.61
CASP3 P42574 1/20 0.52
DPP4 P27487 2/20 0.50
DPP7 Q9UHL4 1/20 0.50
MAPT P10636 1/20 0.48
PKM P14618 1/20 0.48
XBP1 P17861 1/20 0.48
SCN9A Q15858 3/20 0.47
SMPD1 P17405 1/20 0.46
FPR2 P25090 2/20 0.45
HDAC1 Q13547 1/20 0.45
HDAC2 Q92769 1/20 0.45
HDAC8 Q9BY41 1/20 0.45
ADORA3 P0DMS8 1/20 0.44
KDM4E B2RXH2 1/20 0.44
GAA P10253 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
CHRNA7 P36544 2/20 0.43
S1PR1 P21453 2/20 0.42
CHEK2 O96017 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15491561 0.87 SCN10A (0.62) SCN10ACASP3DPP4DPP7MAPT
SCHEMBL15489376 0.86 SCN10A (0.64) SCN10ACASP3DPP4DPP7MAPT
SCHEMBL15498668 0.85 SCN10A (0.67) SCN10ACASP3DPP4DPP7MAPT
SCHEMBL15487665 0.85 SCN10A (0.60) SCN10ACASP3DPP4DPP7MAPT
SCHEMBL1114407 0.84 S1PR1 (0.51) SCN10AMAPTSCN9AGAASMN1; SMN2
SCHEMBL15487340 0.83 SCN10A (0.58) SCN10ACASP3DPP4DPP7MAPT
SCHEMBL15489362 0.83 SCN10A (0.70) SCN10ACASP3DPP4DPP7MAPT
SCHEMBL17513947 0.82 NPC1 (0.57) CASP3MAPTHDAC1SMN1; SMN2S1PR1
SCHEMBL15486814 0.82 HTT (0.62) SCN10ACASP3DPP4DPP7MAPT
SCHEMBL15487139 0.81 SCN10A (0.67) SCN10ACASP3DPP4DPP7MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015130790-A2 SALTS OF HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE BOARD OF REGENTS, UNIVERSITY OF TEXAS SYSTEM (US) 2015-09-03 WO disclosed
WO-2014031936-A2 HETEROCYCLIC MODULATORS OF HIF ACTIVITY FOR TREATMENT OF DISEASE JONES PHILIP (US) 2014-02-27 WO disclosed
EP-2278879-A2 COMPOUNDS, COMPOSITIONS AND METHODS COMPRISING OXADIAZOLE DERIVATIVES Institute for OneWorld Health (US) 2011-02-02 EP disclosed