Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.61 |
| ▸ | MTOR | P42345 | 14/20 | 0.61 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.53 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.53 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.53 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.53 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.53 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1113410 | 0.88 | PIK3CA (0.64) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1114254 | 0.82 | PIK3CA (0.59) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1114125 | 0.82 | PIK3CA (0.59) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL16411857 | 0.76 | PIK3CA (0.57) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1113406 | 0.76 | PIK3CA (0.57) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL337082 | 0.76 | PIK3CA (0.58) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL336616 | 0.76 | PIK3CA (0.55) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL16411763 | 0.75 | PIK3CA (0.84) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL1114212 | 0.75 | PIK3CA (0.62) | PIK3CAMTORPIK3CBPIK3CDPIK3CG | |
| SCHEMBL336680 | 0.75 | PIK3CA (0.53) | PIK3CAMTORPIK3CBPIK3CDPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279188-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | claimed |
| WO-2009146406-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-12-03 | — | — | WO | claimed |
| EP-2279188-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | disclosed |
| WO-2009146406-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-12-03 | — | — | WO | disclosed |