Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 17/20 | 0.59 |
| ▸ | MTOR | P42345 | 7/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.48 |
| ▸ | PIK3R1 | P27986 | 6/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 6/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.48 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.44 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1114254 | 1.00 | PIK3CA (0.59) | PIK3CAMTORHDAC1PIK3R1PIK3CD | |
| SCHEMBL1114214 | 0.82 | PIK3CA (0.61) | PIK3CAMTORHDAC1PIK3R1PIK3CD | |
| SCHEMBL16411763 | 0.75 | PIK3CA (0.84) | PIK3CAMTORHDAC1PIK3R1PIK3CD | |
| SCHEMBL1113742 | 0.74 | PIK3CA (0.63) | PIK3CAMTORHDAC1PIK3R1PIK3CD | |
| SCHEMBL1114120 | 0.74 | PIK3CA (0.63) | PIK3CAMTORHDAC1PIK3R1PIK3CD | |
| SCHEMBL1113727 | 0.74 | PIK3CA (0.63) | PIK3CAMTORHDAC1PIK3R1PIK3CD | |
| SCHEMBL16412047 | 0.74 | PIK3CA (0.78) | PIK3CAMTORHDAC1PIK3R1PIK3CD | |
| SCHEMBL1113410 | 0.72 | PIK3CA (0.64) | PIK3CAMTORHDAC1PIK3R1PIK3CD | |
| SCHEMBL1113665 | 0.72 | PIK3CA (0.55) | PIK3CAMTORHDAC1PIK3R1PIK3CD | |
| SCHEMBL1114171 | 0.71 | PIK3CA (0.56) | PIK3CAMTORHDAC1PIK3R1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2279188-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | Genentech, Inc. (US) | 2011-02-02 | — | — | EP | claimed |
| WO-2009146406-A1 | PURINE PI3K INHIBITOR COMPOUNDS AND METHODS OF USE | GENENTECH, INC. (US) | 2009-12-03 | — | — | WO | claimed |