Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 9/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 10/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11142400 | 1.00 | PTGS2 (0.74) | PTGS2PTGS1BRD4MAPK14EP300 | |
| Flosulide SCHEMBL29454969 | 0.85 | PTGS2 (1.00) | PTGS2PTGS1BRD4MAPK14 | |
| Flosulide SCHEMBL29383035 | 0.85 | PTGS2 (1.00) | PTGS2PTGS1BRD4MAPK14 | |
| Flosulide SCHEMBL195509 | 0.85 | PTGS2 (1.00) | PTGS2PTGS1BRD4MAPK14 | |
| SCHEMBL11176908 | 0.81 | PTGS2 (0.54) | PTGS2PTGS1BRD4 | |
| SCHEMBL11176910 | 0.81 | PTGS2 (0.54) | PTGS2PTGS1BRD4 | |
| SCHEMBL10935984 | 0.80 | PTGS2 (0.71) | PTGS2PTGS1BRD4MAPK14EP300 | |
| SCHEMBL10953840 | 0.77 | PTGS2 (0.67) | PTGS2PTGS1BRD4EP300 | |
| SCHEMBL10955991 | 0.77 | PTGS2 (0.70) | PTGS2PTGS1BRD4MAPK14 | |
| SCHEMBL11177616 | 0.76 | PTGS2 (0.49) | PTGS2PTGS1BRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4375479-A | ANTIINFLAMMATORY AGENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1983-03-01 | — | — | US | disclosed |
| EP-0056956-A2 | Indanyl derivatives their preparation and their use | SCHERING AKTIENGESELLSCHAFT (DE) | 1982-08-04 | — | — | EP | disclosed |