Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 12/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | TNKS | O95271 | 1/20 | 0.39 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | F10 | P00742 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2129926 | 0.85 | MEN1 (0.47) | HPGDALDH1A1MEN1KMT2AGAA | |
| SCHEMBL110178 | 0.76 | HPGD (0.51) | HPGDALDH1A1MEN1KMT2AGAA | |
| SCHEMBL10268215 | 0.72 | NPC1 (0.46) | HPGDALDH1A1MAPTPOLBACSS2 | |
| SCHEMBL4291062 | 0.70 | GPR119 (0.42) | HPGDHRH3TNKSTNKS2F2 | |
| SCHEMBL3838757 | 0.67 | FGFR1 (0.56) | HPGDALDH1A1MEN1KMT2AF2 | |
| SCHEMBL20733066 | 0.67 | HPGD (0.59) | HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL18783301 | 0.66 | HPGD (0.61) | HPGDALDH1A1MGLL | |
| SCHEMBL1376416 | 0.65 | GPR183 (0.53) | HPGDALDH1A1GAAMAPTKDM4E | |
| SCHEMBL31321944 | 0.65 | FGFR1 (0.47) | HPGDALDH1A1MEN1KMT2AGAA | |
| SCHEMBL20732997 | 0.65 | FGFR1 (0.64) | HPGDALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2424843-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | Novartis AG (CH) | 2012-03-07 | — | — | EP | disclosed |
| WO-2010125402-A1 | IMIDAZOLE DERIVATIVES AND THEIR USE AS MODULATORS OF CYCLIN DEPENDENT KINASES | NOVARTIS AG (CH) | 2010-11-04 | — | — | WO | disclosed |