Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | PREP | P48147 | 6/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | HTR1A | P08908 | 4/20 | 0.36 |
| ▸ | HTR7 | P34969 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11389986 | 0.83 | ACE (0.44) | KMT2APREPTDP1L3MBTL1ACE | |
| SCHEMBL11149876 | 0.83 | ACE (0.55) | KMT2AACE | |
| SCHEMBL11148777 | 0.81 | KMT2A (0.54) | KMT2APREPTDP1L3MBTL1ACE | |
| SCHEMBL11044573 | 0.81 | KMT2A (0.45) | KMT2AACE | |
| SCHEMBL11050571 | 0.81 | KMT2A (0.45) | KMT2AACE | |
| SCHEMBL11047878 | 0.81 | KMT2A (0.45) | KMT2AACE | |
| SCHEMBL11147278 | 0.80 | KMT2A (0.50) | KMT2APREPTDP1L3MBTL1ACE | |
| SCHEMBL11372947 | 0.79 | KMT2A (0.51) | KMT2APREPKDM4EMEN1 | |
| SCHEMBL11398821 | 0.73 | ACE (0.63) | ACE | |
| SCHEMBL10923194 | 0.72 | ACE (0.46) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0012845-B1 | TETRAHYDROISOQUINOLINE COMPOUNDS, PROCESS FOR PREPARING SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Tanabe Seiyaku Co., Ltd. (JP) | 1983-06-22 | — | — | EP | disclosed |
| US-4256751-A | HYPOTENSIVE AGENTS | TANABE SEIYAKU CO., LTD. (JP) | 1981-03-17 | — | — | US | disclosed |