Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 5/20 | 0.41 |
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | ICAM1 | P05362 | 2/20 | 0.32 |
| ▸ | SELE | P16581 | 2/20 | 0.32 |
| ▸ | VCAM1 | P19320 | 2/20 | 0.32 |
| ▸ | AR | P10275 | 1/20 | 0.31 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9464793 | 0.99 | MAPT (0.42) | MAPTALDH1A1L3MBTL1HPGDTDP1 | |
| Zinc Ion SCHEMBL11063710 | 0.99 | MAPT (0.42) | MAPTALDH1A1L3MBTL1HPGDTDP1 | |
| Hydrochloric Acid SCHEMBL11147817 | 0.97 | MAPT (0.41) | MAPTALDH1A1L3MBTL1HPGDTDP1 | |
| Hydrochloric Acid SCHEMBL11359417 | 0.97 | MAPT (0.41) | MAPTALDH1A1L3MBTL1HPGDTDP1 | |
| Hydrochloric Acid SCHEMBL8082567 | 0.97 | MAPT (0.44) | MAPTALDH1A1L3MBTL1HPGDTDP1 | |
| SCHEMBL5665263 | 0.97 | MAPT (0.43) | MAPTALDH1A1L3MBTL1HPGDTDP1 | |
| Hydrochloric Acid SCHEMBL11359415 | 0.96 | MAPT (0.43) | MAPTALDH1A1L3MBTL1HPGDTDP1 | |
| SCHEMBL11063706 | 0.96 | MAPT (0.42) | MAPTALDH1A1L3MBTL1HPGDTDP1 | |
| SCHEMBL10385367 | 0.92 | MAPT (0.39) | MAPTALDH1A1L3MBTL1HPGDTDP1 | |
| SCHEMBL11881030 | 0.92 | MAPT (0.39) | MAPTALDH1A1L3MBTL1HPGDTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205989-A | Dry system image producing element | KIMOTO & CO., LTD. (JP) | 1980-06-03 | — | — | US | claimed |
| US-4391894-A | BASIC DYE REACTED WITH ORGANIC ACID DISSOLVED IN A PHOTOSENSITIVE DIAZO COMPOSITION | POLYCHROME CORPORATION (US) | 1983-07-05 | — | — | US | disclosed |
| US-4374193-A | Photosensitive material and process for developing the same | KIMOTO & CO., LTD. (JP) | 1983-02-15 | — | — | US | disclosed |
| US-4347300-A | CONCURRENT PRODUCTION OF NEGATIVE AND POSITIVE IMAGE; DIAZOTIXZATION; LITHOGRAPHY | POLYCHROME CORPORATION (US) | 1982-08-31 | — | — | US | disclosed |
| US-4296193-A | Photosensitive positive diazo material with copolymer of acrylamide and diacetoneacrylamide and a process for developing to form color relief image | KIMOTO & CO., LTD. (JP) | 1981-10-20 | — | — | US | disclosed |
| US-4205989-A | Dry system image producing element | KIMOTO & CO., LTD. (JP) | 1980-06-03 | — | — | US | disclosed |