Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.50 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CA2 | P00918 | 1/20 | 0.48 |
| ▸ | CA7 | P43166 | 1/20 | 0.48 |
| ▸ | CA9 | Q16790 | 1/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 4/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 4/20 | 0.46 |
| ▸ | TAS1R2 | Q8TE23 | 3/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8029932 | 0.89 | PDPK1 (0.61) | MTNR1AMTNR1BPDPK1CA12CA1 | |
| SCHEMBL2466144 | 0.89 | PDPK1 (0.61) | MTNR1AMTNR1BPDPK1CA12CA1 | |
| SCHEMBL600676 | 0.89 | PDPK1 (0.61) | MTNR1AMTNR1BPDPK1CA12CA1 | |
| SCHEMBL1988494 | 0.89 | PDPK1 (0.61) | MTNR1AMTNR1BPDPK1CA12CA1 | |
| SCHEMBL13165574 | 0.81 | MTNR1A (0.47) | MTNR1AMTNR1BCA12CA1CA2 | |
| SCHEMBL8340594 | 0.80 | HTT (0.68) | TAS1R3TAS1R1TAS1R2HTTKMT2A | |
| SCHEMBL6445345 | 0.80 | HTT (0.68) | TAS1R3TAS1R1TAS1R2HTTKMT2A | |
| SCHEMBL31301105 | 0.80 | HTT (0.68) | TAS1R3TAS1R1TAS1R2HTTKMT2A | |
| SCHEMBL607818 | 0.80 | HTT (0.68) | TAS1R3TAS1R1TAS1R2HTTKMT2A | |
| SCHEMBL19658435 | 0.79 | EPHX1 (0.63) | TAS1R3TAS1R1TAS1R2HTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4414154-A | ANXIOLYTIC, ANTIDEPRESSANT, ANTICONVULSANT, MUSCLE RELAXANTS | MERCK & CO. INC. (US) | 1983-11-08 | — | — | US | disclosed |
| US-4374838-A | USEFUL AS ANXIOLYTICS, ANTIDEPRESSANTS, ANTICONVULSANTS, MUSCLE RELAXANTS AND IN THE TREATMENT OF PARKINSONS'S DISEASE | MERCK & CO., INC. (US) | 1983-02-22 | — | — | US | disclosed |
| US-4329465-A | ANXIOLYTICS, ANTIDEPRESSANTS, ANTICONVULSANTS, MUSCLE RELAXANTS, TREATMENT OF NERVOUS SYSTEM DISORDERS | MERCK & CO., INC. (US) | 1982-05-11 | — | — | US | disclosed |