Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.44 |
| ▸ | RAB9A | P51151 | 6/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 4/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 5/20 | 0.32 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.32 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.32 |
| ▸ | RELA | Q04206 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 5/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11148348 | 1.00 | NPC1 (0.44) | NPC1RAB9AL3MBTL1KMT2AMEN1 | |
| SCHEMBL11454683 | 0.81 | CYP3A4 (0.56) | NPC1RAB9AL3MBTL1KMT2AMEN1 | |
| SCHEMBL6067530 | 0.81 | CYP3A4 (0.56) | NPC1RAB9AL3MBTL1KMT2AMEN1 | |
| Hydrochloric Acid SCHEMBL11533363 | 0.79 | CYP3A4 (0.55) | NPC1RAB9AL3MBTL1KMT2AMEN1 | |
| SCHEMBL12305572 | 0.79 | NPC1 (0.47) | NPC1RAB9AL3MBTL1KMT2AMEN1 | |
| SCHEMBL11144321 | 0.78 | CYP3A4 (0.37) | NPC1RAB9AL3MBTL1KMT2AMEN1 | |
| SCHEMBL11144324 | 0.78 | CYP3A4 (0.37) | NPC1RAB9AL3MBTL1KMT2AMEN1 | |
| SCHEMBL11856894 | 0.77 | DHODH (0.45) | NPC1RAB9AL3MBTL1KMT2AMEN1 | |
| SCHEMBL11857939 | 0.75 | CYP2C9 (0.41) | NPC1RAB9AKMT2AMEN1CYP3A4 | |
| SCHEMBL11285388 | 0.74 | CYP3A4 (0.68) | NPC1RAB9AL3MBTL1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4413013-A | N-(((ARYLFORMAMIDOYL)METHYLAMINO)THIO)-N-SUBSTITUTED SULFONAMIDES | THE UPJOHN COMPANY (US) | 1983-11-01 | — | — | US | disclosed |