SCHEMBL11148734

SCHEMBL11148734

CCC(CC)=C(c1ccccc1)c1ccc2nc(N)n(S(=O)(=O)C(C)C)c2c1

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
PI4KB Q9UBF8 1/20 0.67
MAPK14 Q16539 19/20 0.50
CYP3A4 P08684 8/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11149101 0.88 PI4KB (0.71) PI4KBMAPK14CYP3A4
SCHEMBL11148839 0.87 PI4KB (0.70) PI4KBMAPK14CYP3A4
SCHEMBL11160244 0.86 PI4KB (0.69) PI4KBMAPK14CYP3A4
SCHEMBL4837467 0.85 PI4KB (0.74) PI4KBMAPK14CYP3A4
SCHEMBL10906292 0.85 PI4KB (0.74) PI4KBMAPK14CYP3A4
SCHEMBL11157833 0.85 PI4KB (0.67) PI4KBMAPK14CYP3A4
SCHEMBL11152374 0.85 PI4KB (0.48) PI4KBMAPK14CYP3A4
SCHEMBL11076745 0.84 PI4KB (0.62) PI4KBMAPK14CYP3A4
SCHEMBL11150664 0.84 PI4KB (0.66) PI4KBMAPK14CYP3A4
SCHEMBL11164281 0.83 PI4KB (0.60) PI4KBMAPK14CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4401817-A ANTIVIRAL AGENTS ELI LILLY AND COMPANY (US) 1983-08-30 US disclosed
US-4338329-A COMBATTING RHINOVIRUSES ELI LILLY AND COMPANY (US) 1982-07-06 US disclosed
US-4289782-A PARTICULARLY FOR INHIBITING GROWTH OF RHINOVIRUSES ELI LILLY AND COMPANY (US) 1981-09-15 US disclosed
US-4230868-A α-Alkyl-α-hydroxybenzyl-substituted 1-sulfonylbenzimidazoles ELI LILLY AND COMPANY (US) 1980-10-28 US disclosed
US-4174454-A VIRICIDES ELI LILLY AND COMPANY (US) 1979-11-13 US disclosed
US-4118742-A VIRICIDES ELI LILLY AND COMPANY (US) 1978-10-03 US disclosed