Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.67 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.67 |
| ▸ | HTR1A | P08908 | 3/20 | 0.52 |
| ▸ | ADRA1D | P25100 | 3/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | TLR4 | O00206 | 1/20 | 0.51 |
| ▸ | ADRB2 | P07550 | 4/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11150348 | 0.87 | TSHR (0.61) | TSHRL3MBTL1HTR1AADRA1DADRA1A | |
| SCHEMBL13082245 | 0.87 | ADRB2 (0.64) | HTR1AADRA1DADRA1AADRA1BTLR4 | |
| SCHEMBL568103 | 0.77 | CYP1A2 (0.72) | TSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL568104 | 0.77 | CYP1A2 (0.72) | TSHRL3MBTL1SMN1; SMN2 | |
| SCHEMBL17950816 | 0.76 | TLR4 (0.65) | HTR1AADRA1DADRA1ATLR4ADRB2 | |
| SCHEMBL16550063 | 0.75 | ADRB2 (0.73) | HTR1AADRA1DADRA1ATLR4ADRB2 | |
| SCHEMBL17950815 | 0.75 | ADRB2 (0.70) | HTR1AADRA1DADRA1ATLR4ADRB2 | |
| SCHEMBL19897549 | 0.75 | ADRB2 (0.50) | TSHRL3MBTL1SMN1; SMN2ADRB2 | |
| SCHEMBL19916256 | 0.75 | ADRB2 (0.50) | TSHRL3MBTL1SMN1; SMN2ADRB2 | |
| SCHEMBL7410044 | 0.75 | ADRB2 (0.67) | HTR1AADRA1DADRA1ATLR4ADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0014951-B1 | HETEROCYCLIC OXYPROPANOLAMINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1983-01-12 | — | — | EP | disclosed |