Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11165095 | 0.98 | POLB (0.45) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL11155171 | 0.83 | POLB (0.47) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL11345797 | 0.80 | L3MBTL1 (0.37) | SMN1; SMN2NPC1RAB9AMAPTCYP1A2 | |
| SCHEMBL11161665 | 0.79 | NOTUM (0.54) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL11163537 | 0.75 | L3MBTL1 (0.56) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL24258049 | 0.74 | NPC1 (0.50) | POLBSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL11176476 | 0.73 | L3MBTL1 (0.46) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL11156475 | 0.71 | POLB (0.49) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL11344812 | 0.70 | L3MBTL1 (0.63) | POLBSMN1; SMN2NPC1RAB9AMAPT | |
| Hydrochloric Acid SCHEMBL11151688 | 0.70 | POLB (0.47) | POLBSMN1; SMN2NPC1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0008356-B1 | OXADIAZOLE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL COMPOSITIONS | THE WELLCOME FOUNDATION LIMITED (GB) | 1983-07-20 | — | — | EP | disclosed |
| US-4294843-A | MALARIA | BURROUGHS WELLCOME CO. (US) | 1981-10-13 | — | — | US | disclosed |
| EP-0008356-A1 | Oxadiazole derivatives, process for their preparation and their pharmaceutical compositions | THE WELLCOME FOUNDATION LIMITED (GB) | 1980-03-05 | — | — | EP | disclosed |