Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | PPIB | P23284 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.37 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.37 |
| ▸ | RELA | Q04206 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 3/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28202516 | 0.92 | ALDH1A1 (0.47) | ALDH1A1PPIBTSHRPKMATM | |
| SCHEMBL27587 | 0.90 | ALDH1A1 (0.54) | ALDH1A1PPIBTSHRPKMATM | |
| SCHEMBL10603717 | 0.90 | ALDH1A1 (0.54) | ALDH1A1PPIBTSHRPKMATM | |
| SCHEMBL3110019 | 0.89 | ALDH1A1 (0.41) | ALDH1A1PPIBTSHRPKMATM | |
| SCHEMBL22389768 | 0.87 | HDAC3 (0.50) | ALDH1A1SIGMAR1HDAC3HDAC4HDAC1 | |
| Hydrochloric Acid SCHEMBL3228756 | 0.86 | HDAC3 (0.49) | ALDH1A1SIGMAR1HDAC3HDAC4HDAC1 | |
| SCHEMBL21037722 | 0.84 | HDAC3 (0.51) | PPIBSIGMAR1HDAC3HDAC4HDAC1 | |
| SCHEMBL21037721 | 0.81 | CYP2D6 (0.44) | ALDH1A1PPIBMAPTSIGMAR1HDAC3 | |
| SCHEMBL21383845 | 0.81 | HDAC3 (0.48) | SIGMAR1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL28549888 | 0.77 | HDAC3 (0.43) | PPIBSIGMAR1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003084-B1 | SPIROBENZOFURANONE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | Takeda Chemical Industries, Ltd. (JP) | 1982-02-24 | — | — | EP | claimed |
| US-4284644-A | Spirobenzofuranone compounds | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1981-08-18 | — | — | US | claimed |
| JP-55064582-A | — | — | None | — | — | JP | disclosed |
| JP-56005473-A | — | — | None | — | — | JP | disclosed |
| JP-54098752-A | — | — | None | — | — | JP | disclosed |
| EP-0018830-B1 | SPIROBENZOFURANONES, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Takeda Chemical Industries, Ltd. (JP) | 1983-06-08 | — | — | EP | disclosed |
| EP-0003084-B1 | SPIROBENZOFURANONE COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS MEDICINES | Takeda Chemical Industries, Ltd. (JP) | 1982-02-24 | — | — | EP | disclosed |
| JP-S565473-A | SPIRO COMPOUND AND ITS PREPARATION | TAKEDA CHEM IND LTD | 1981-01-20 | — | — | JP | disclosed |
| EP-0018830-A2 | Spirobenzofuranones, their production and pharmaceutical compositions containing them | Takeda Chemical Industries, Ltd. (JP) | 1980-11-12 | — | — | EP | disclosed |
| JP-S5564582-A | SPIRO COMPOUND AND ITS PREPARATION | TAKEDA CHEM IND LTD | 1980-05-15 | — | — | JP | disclosed |
| JP-S5498752-A | SPIRO COMPOUND AND ITS PREPARATION | TAKEDA CHEM IND LTD | 1979-08-03 | — | — | JP | disclosed |
| EP-0003084-A1 | Spirobenzofuranone compounds, processes for their preparation and their use as medicines | Takeda Chemical Industries, Ltd. (JP) | 1979-07-25 | — | — | EP | disclosed |