Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 4/20 | 0.60 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.60 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.60 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 3/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | HTT | P42858 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | MET | P08581 | 1/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.48 |
| ▸ | GABRD | O14764 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.48 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3843267 | 0.89 | MEN1 (0.60) | MEN1KMT2AKDM4EHTTHSD17B10 | |
| SCHEMBL11162605 | 0.85 | KDM4E (0.53) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL11165335 | 0.81 | HTT (0.50) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL11218973 | 0.81 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL7679338 | 0.80 | KDM4E (0.57) | MEN1KMT2AKDM4EHTTHSD17B10 | |
| SCHEMBL3839136 | 0.80 | KDM4E (0.60) | MEN1KMT2AKDM4EHTTHSD17B10 | |
| SCHEMBL16117950 | 0.77 | KDM4E (0.69) | MEN1KMT2AKDM4EHTTHSD17B10 | |
| SCHEMBL11399679 | 0.77 | KDM4E (0.58) | MEN1KMT2AKDM4EHTTHSD17B10 | |
| SCHEMBL23479895 | 0.77 | PDE4A (0.45) | PDE4APDE4BPDE4CPDE4DMEN1 | |
| SCHEMBL11161995 | 0.77 | MEN1 (0.53) | PDE4APDE4BPDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-57042676-A | — | — | None | — | — | JP | disclosed |
| EP-0030835-B1 | DERIVATIVES OF 2-SUBSTITUTED-6-PHENYL-3(2H)PYRIDAZINONE, THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MORISHITA PHARMACEUTICAL CO. LTD. (JP) | 1983-05-11 | — | — | EP | disclosed |
| JP-S5742676-A | PYRIDAZINONE DERIVATIVE | MORISHITA SEIYAKU KK | 1982-03-10 | — | — | JP | disclosed |
| EP-0030835-A1 | Derivatives of 2-substituted-6-phenyl-3(2H)pyridazinone, their production and pharmaceutical compositions containing them | MORISHITA PHARMACEUTICAL CO. LTD. (JP) | 1981-06-24 | — | — | EP | disclosed |