Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 12/20 | 0.66 |
| ▸ | PGR | P06401 | 7/20 | 0.66 |
| ▸ | HIF1A | Q16665 | 5/20 | 0.66 |
| ▸ | LMNA | P02545 | 4/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 3/20 | 0.61 |
| ▸ | NR1I2 | O75469 | 2/20 | 0.61 |
| ▸ | ABCC3 | O15438 | 2/20 | 0.61 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.50 |
| ▸ | AR | P10275 | 3/20 | 0.50 |
| ▸ | NR3C2 | P08235 | 2/20 | 0.50 |
| ▸ | TNF | P01375 | 1/20 | 0.50 |
| ▸ | IL6 | P05231 | 1/20 | 0.50 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.50 |
| ▸ | GLUL | P15104 | 1/20 | 0.50 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.50 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11156311 | 0.97 | NR3C1 (0.65) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11158096 | 0.95 | NR3C1 (0.63) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11163133 | 0.95 | NR3C1 (0.73) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11162651 | 0.94 | NR3C1 (0.68) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11429090 | 0.92 | NR3C1 (0.63) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL9336692 | 0.91 | NR3C1 (0.63) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11424746 | 0.91 | NR3C1 (0.61) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11432975 | 0.91 | NR3C1 (0.62) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11438036 | 0.91 | NR3C1 (0.68) | NR3C1PGRHIF1ALMNACYP3A4 | |
| SCHEMBL11569896 | 0.90 | NR3C1 (0.63) | NR3C1PGRHIF1ALMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4377575-A | Corticoid-17-(alkyl carbonates) and process for their manufacture | HOECHST AKTIENGESELLSCHAFT (DE) | 1983-03-22 | — | — | US | disclosed |
| EP-0004975-B1 | 17-ALKYLCARBONATES OF CORTICOIDS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICINES AGAINST DERMATOSES | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-02-17 | — | — | EP | disclosed |
| US-4242334-A | ANTIINFLAMMATORY AGENTS; SKIN DISORDERS | HOECHST AKTIENGESELLSCHAFT (DE) | 1980-12-30 | — | — | US | disclosed |
| EP-0004975-A2 | 17-Alkylcarbonates of corticoids, process for their preparation and their use as medicines against dermatoses | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-10-31 | — | — | EP | disclosed |