Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 7/20 | 0.46 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.45 |
| ▸ | REV1 | Q9UBZ9 | 1/20 | 0.44 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 2/20 | 0.42 |
| ▸ | DRD3 | P35462 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11154508 | 0.86 | DRD1 (0.52) | DRD1HTR2ADRD2CYP2D6 | |
| SCHEMBL10744054 | 0.85 | GRIN1 (0.45) | GRIN1GRIN2BREV1CYP19A1DRD1 | |
| SCHEMBL11157874 | 0.84 | DRD1 (0.57) | DRD1HTR2ACYP2D6 | |
| SCHEMBL11152502 | 0.81 | GRIN1 (0.48) | GRIN1GRIN2BREV1DRD1CYP3A4 | |
| Hydrochloric Acid SCHEMBL11706761 | 0.80 | CYP2D6 (0.49) | GRIN1GRIN2BDRD1DRD2CYP3A4 | |
| Hydrochloric Acid SCHEMBL11710083 | 0.76 | CYP2D6 (0.47) | GRIN1GRIN2BDRD1DRD2CYP3A4 | |
| SCHEMBL11157379 | 0.73 | DRD1 (0.70) | DRD1DRD2CYP3A4CYP2D6 | |
| SCHEMBL11157862 | 0.72 | DRD1 (0.69) | GRIN1GRIN2BDRD1HTR2ADRD2 | |
| SCHEMBL9764247 | 0.72 | DRD1 (0.67) | DRD1HTR2ADRD2CYP3A4CYP2D6 | |
| SCHEMBL9764239 | 0.72 | DRD1 (0.67) | DRD1HTR2ADRD2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4382029-A | Process useful for preparing 7,8-acetamido, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE BECKMAN CORPORATION (US) | 1983-05-03 | — | — | US | disclosed |
| EP-0033632-B1 | 7,8-AMINO, HYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1983-03-30 | — | — | EP | disclosed |
| US-4327023-A | Intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1982-04-27 | — | — | US | disclosed |
| US-4284556-A | 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1981-08-18 | — | — | US | disclosed |
| EP-0033632-A2 | 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, process for their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1981-08-12 | — | — | EP | disclosed |