Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 17/20 | 0.63 |
| ▸ | DRD2 | P14416 | 5/20 | 0.62 |
| ▸ | THPO | P40225 | 2/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.55 |
| ▸ | MTOR | P42345 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.54 |
| ▸ | BLM | P54132 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11256942 | 0.88 | DRD1 (0.76) | DRD1DRD2THPOHSD17B10MTOR | |
| Bromide SCHEMBL11252142 | 0.86 | DRD1 (0.76) | DRD1DRD2THPOHSD17B10MTOR | |
| Hydrochloric Acid SCHEMBL11165963 | 0.86 | DRD1 (0.74) | DRD1DRD2THPOHSD17B10MTOR | |
| Bromide SCHEMBL11542259 | 0.85 | DRD1 (0.74) | DRD1DRD2THPOHSD17B10MTOR | |
| SCHEMBL11162866 | 0.85 | DRD1 (0.65) | DRD1DRD2THPOHSD17B10MTOR | |
| SCHEMBL14495015 | 0.80 | DRD1 (0.79) | DRD1DRD2THPOHSD17B10MTOR | |
| SCHEMBL7321723 | 0.77 | DRD1 (0.74) | DRD1DRD2THPOHSD17B10MTOR | |
| SCHEMBL7323497 | 0.77 | DRD1 (1.00) | DRD1DRD2THPOHSD17B10MTOR | |
| SCHEMBL8504203 | 0.76 | DRD1 (0.60) | DRD1DRD2THPOHSD17B10MTOR | |
| SCHEMBL9764281 | 0.76 | DRD1 (0.75) | DRD1DRD2THPOHSD17B10MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4382029-A | Process useful for preparing 7,8-acetamido, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE BECKMAN CORPORATION (US) | 1983-05-03 | — | — | US | disclosed |
| US-4327023-A | Intermediates for preparing 7,8-amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1982-04-27 | — | — | US | disclosed |
| US-4284556-A | 7,8-Amino, hydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1981-08-18 | — | — | US | disclosed |