Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.64 |
| ▸ | ADRA2B known ✓ | P18089 | 1/20 | 0.60 |
| ▸ | ADRA2C known ✓ | P18825 | 1/20 | 0.60 |
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.60 |
| ▸ | HTR1B known ✓ | P28222 | 1/20 | 0.60 |
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.60 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.60 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.60 |
| ▸ | DRD1 | P21728 | 15/20 | 0.76 |
| ▸ | DRD2 | P14416 | 8/20 | 0.76 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | MAPT | P10636 | 4/20 | 0.65 |
| ▸ | PMP22 | Q01453 | 4/20 | 0.65 |
| ▸ | BLM | P54132 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.65 |
| ▸ | THPO | P40225 | 4/20 | 0.63 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.63 |
| ▸ | MTOR | P42345 | 2/20 | 0.63 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11542259 | 0.99 | DRD1 (0.74) | DRD1DRD2KDM4EMAPTPMP22 | |
| SCHEMBL11256942 | 0.99 | DRD1 (0.76) | DRD1DRD2KDM4EMAPTPMP22 | |
| Hydrochloric Acid SCHEMBL11165963 | 0.97 | DRD1 (0.74) | DRD1DRD2KDM4EMAPTPMP22 | |
| SCHEMBL14495015 | 0.88 | DRD1 (0.79) | DRD1DRD2KDM4EMAPTPMP22 | |
| SCHEMBL11160306 | 0.86 | DRD1 (0.63) | DRD1DRD2KDM4EMAPTPMP22 | |
| SCHEMBL11162866 | 0.86 | DRD1 (0.65) | DRD1DRD2KDM4EMAPTPMP22 | |
| Bromide SCHEMBL29634894 | 0.86 | DRD1 (1.00) | DRD1DRD2KDM4EMAPTPMP22 | |
| Bromide SCHEMBL7321240 | 0.86 | DRD1 (1.00) | DRD1DRD2KDM4EMAPTPMP22 | |
| Bromide SCHEMBL7320300 | 0.86 | DRD1 (1.00) | DRD1DRD2KDM4EMAPTPMP22 | |
| SCHEMBL7321723 | 0.85 | DRD1 (0.74) | DRD1DRD2KDM4EMAPTPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0002327-B1 | PHARMACOLOGICALLY ACTIVE 6-LOWER ALKYL-7,8-DIHYDROXY-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES, METHOD OF PREPARING THEM AND INTERMEDIATES | SMITHKLINE BECKMAN CORPORATION (US) | 1982-08-04 | — | — | EP | disclosed |
| US-4342686-A | Intermediates for preparing 6-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines | SMITHKLINE CORPORATION (US) | 1982-08-03 | — | — | US | disclosed |
| US-4265889-A | DOPAMINERGIC, HYPOTENSIVE | SMITHKLINE CORPORATION (US) | 1981-05-05 | — | — | US | disclosed |
| EP-0002327-A1 | Pharmacologically active 6-lower alkyl-7,8-dihydroxy-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepines, method of preparing them and intermediates | SMITHKLINE BECKMAN CORPORATION (US) | 1979-06-13 | — | — | EP | disclosed |