Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.50 |
| ▸ | EGLN2 | Q96KS0 | 16/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | FEN1 | P39748 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28993794 | 0.87 | EGLN2 (0.50) | EGLN1EGLN2LRRK2 | |
| Acetic Acid SCHEMBL28993792 | 0.83 | EGLN1 (0.64) | EGLN1EGLN2 | |
| SCHEMBL27861661 | 0.83 | PARP10 (0.41) | EGLN1ABL1 | |
| Acetic Acid Methyl Ester SCHEMBL28993806 | 0.83 | EGLN1 (0.63) | EGLN1EGLN2 | |
| SCHEMBL30394217 | 0.82 | EGLN1 (0.67) | EGLN1EGLN2 | |
| SCHEMBL27592826 | 0.81 | KMT2A (0.37) | — | |
| SCHEMBL21670013 | 0.81 | EGLN1 (0.52) | EGLN1EGLN2LRRK2 | |
| SCHEMBL20774561 | 0.81 | EGLN1 (0.50) | EGLN1EGLN2LRRK2 | |
| SCHEMBL28556240 | 0.81 | THRA (0.51) | EGLN1EGLN2LRRK2 | |
| SCHEMBL28570242 | 0.81 | THRA (0.52) | EGLN1EGLN2LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1919463-B9 | USE OF HIF 1ALFA MODULATORS FOR TREATMENT OF CANCER | FIBROGEN INC (US) | 2011-02-02 | — | — | EP | claimed |
| EP-1919463-B1 | USE OF HIF 1ALFA MODULATORS FOR TREATMENT OF CANCER | FIBROGEN INC (US) | 2010-06-09 | — | — | EP | claimed |
| CN-113121438-B | Preparation method of isoquinolinones compound | 江苏希迪制药有限公司 | 2023-05-23 | — | — | CN | disclosed |
| CN-112679431-B | Method for preparing isoquinolinones compound | 上海迪赛诺化学制药有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-112679430-B | Method for preparing isoquinolinones compound | 上海迪赛诺化学制药有限公司 | 2023-05-05 | — | — | CN | disclosed |
| CN-113121438-A | Preparation method of isoquinolone compound | 安礼特（上海）医药科技有限公司 | 2021-07-16 | — | — | CN | disclosed |
| CN-112679431-A | Method for preparing isoquinolone compound | 上海迪赛诺化学制药有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-112679430-A | Method for preparing isoquinolone compound | 上海迪赛诺化学制药有限公司 | 2021-04-20 | — | — | CN | disclosed |