Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 8/20 | 0.43 |
| ▸ | DRD2 | P14416 | 8/20 | 0.43 |
| ▸ | DRD5 | P21918 | 4/20 | 0.43 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
| ▸ | DRD4 | P21917 | 3/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11152828 | 0.89 | DRD2 (0.47) | DRD1DRD2DRD5DRD3DRD4 | |
| SCHEMBL11159788 | 0.86 | DRD1 (0.48) | DRD1DRD2DRD5DRD3DRD4 | |
| SCHEMBL11155684 | 0.83 | DRD2 (0.41) | DRD1DRD2DRD5DRD3DRD4 | |
| SCHEMBL11160741 | 0.81 | SMN1; SMN2 (0.38) | DRD1DRD2DRD5DRD3DRD4 | |
| SCHEMBL11160737 | 0.79 | DRD1 (0.43) | DRD1DRD2DRD5DRD3DRD4 | |
| SCHEMBL11168165 | 0.79 | SMN1; SMN2 (0.36) | DRD1DRD2DRD5DRD3DRD4 | |
| SCHEMBL11171833 | 0.78 | KDM4E (0.38) | DRD1DRD2DRD5DRD3DRD4 | |
| SCHEMBL11158084 | 0.78 | DRD2 (0.37) | DRD1DRD2DRD5DRD3DRD4 | |
| Hydrochloric Acid SCHEMBL11193597 | 0.78 | SMN1; SMN2 (0.39) | DRD1DRD2DRD5DRD3DRD4 | |
| SCHEMBL11162390 | 0.76 | KDM4E (0.38) | DRD1DRD2DRD5DRD3DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0080012-A1 | 6-Chloro-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, its acid addition salts and its use as an intermediate | SMITHKLINE BECKMAN CORPORATION (US) | 1983-06-01 | — | — | EP | disclosed |
| EP-0007070-B1 | 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS HAVING DOPAMINE RECEPTOR BLOCKING ACTIVITY | SMITHKLINE BECKMAN CORPORATION (US) | 1983-01-19 | — | — | EP | disclosed |
| US-4265890-A | ANTIPSYCHOTIC, ANTIEMETICS | SMITHKLINE CORPORATION (US) | 1981-05-05 | — | — | US | disclosed |
| EP-0007070-A1 | 2,3,4,5-Tetrahydro-1H-3-Benzazepines, process for their production and pharmaceutical compositions having dopamine receptor blocking activity | SMITHKLINE BECKMAN CORPORATION (US) | 1980-01-23 | — | — | EP | disclosed |