Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 4/20 | 0.60 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | CLK1 | P49759 | 1/20 | 0.48 |
| ▸ | CLK2 | P49760 | 1/20 | 0.48 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.44 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | F5 | P12259 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116160 | 1.00 | HTR2A (0.60) | HTR2ACA2CA1CLK1CLK2 | |
| SCHEMBL12899354 | 0.89 | HTR2A (0.50) | HTR2ACA2CA1CLK1CLK2 | |
| SCHEMBL1116262 | 0.83 | HTR2A (0.54) | HTR2ACA2CA1CLK1CLK2 | |
| SCHEMBL1116264 | 0.83 | HTR2A (0.54) | HTR2ACA2CA1CLK1CLK2 | |
| SCHEMBL1116039 | 0.80 | MAPT (0.41) | CLK1CLK2CLK4GSK3BPIK3CG | |
| SCHEMBL1116038 | 0.80 | MAPT (0.41) | CLK1CLK2CLK4GSK3BPIK3CG | |
| SCHEMBL1116029 | 0.79 | PIK3CG (0.49) | HTR2ACA2CA1CLK1CLK2 | |
| SCHEMBL1116026 | 0.79 | PIK3CG (0.49) | HTR2ACA2CA1CLK1CLK2 | |
| SCHEMBL6858716 | 0.79 | PIK3CG (0.49) | HTR2ACA2CA1CLK1CLK2 | |
| SCHEMBL1116040 | 0.78 | HTR2A (0.51) | HTR2ACA2CA1CLK1CLK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |
| EP-2281824-A1 | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders | NOSCIRA, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |