Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CG | P48736 | 4/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 4/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.45 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.43 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.43 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.41 |
| ▸ | ESRRA | P11474 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116026 | 1.00 | PIK3CG (0.49) | PIK3CGPIK3CAHTR2ACA2CA1 | |
| SCHEMBL6858716 | 1.00 | PIK3CG (0.49) | PIK3CGPIK3CAHTR2ACA2CA1 | |
| SCHEMBL12899354 | 0.79 | HTR2A (0.50) | PIK3CGPIK3CAHTR2ACA2CA1 | |
| SCHEMBL1116160 | 0.79 | HTR2A (0.60) | PIK3CGHTR2ACA2CA1CLK1 | |
| SCHEMBL1116236 | 0.77 | ALDH1A1 (0.56) | PIK3CGPIK3CASLC1A3MAPTHPGD | |
| SCHEMBL1116037 | 0.76 | HTR2A (0.51) | PIK3CGHTR2ACA2CA1CLK1 | |
| SCHEMBL1116040 | 0.76 | HTR2A (0.51) | PIK3CGHTR2ACA2CA1CLK1 | |
| SCHEMBL12900302 | 0.75 | HTR2A (0.41) | PIK3CGPIK3CAHTR2ACA2CA1 | |
| SCHEMBL1116163 | 0.73 | HTR2A (0.42) | PIK3CGPIK3CAHTR2ACA2CA1 | |
| SCHEMBL1116161 | 0.73 | HTR2A (0.42) | PIK3CGPIK3CAHTR2ACA2CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |
| EP-2281824-A1 | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders | NOSCIRA, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |