Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 15/20 | 0.64 |
| ▸ | DYRK1A | Q13627 | 14/20 | 0.64 |
| ▸ | PIM1 | P11309 | 13/20 | 0.64 |
| ▸ | DYRK3 | O43781 | 12/20 | 0.64 |
| ▸ | CSNK2A2 | P19784 | 12/20 | 0.64 |
| ▸ | CSNK2B | P67870 | 12/20 | 0.64 |
| ▸ | CSNK2A1 | P68400 | 12/20 | 0.64 |
| ▸ | CSNK2A3 | Q8NEV1 | 12/20 | 0.64 |
| ▸ | DYRK1B | Q9Y463 | 12/20 | 0.64 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.61 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.61 |
| ▸ | BRAF | P15056 | 1/20 | 0.61 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 3/20 | 0.43 |
| ▸ | GSK3A | P49840 | 2/20 | 0.41 |
| ▸ | GSK3B | P49841 | 2/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.41 |
| ▸ | CNR1 | P21554 | 1/20 | 0.41 |
| ▸ | CLK1 | P49759 | 1/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1116220 | 1.00 | DYRK2 (0.64) | DYRK2DYRK1APIM1DYRK3CSNK2A2 | |
| SCHEMBL23987104 | 0.78 | DYRK2 (1.00) | DYRK2DYRK1APIM1DYRK3CSNK2A2 | |
| SCHEMBL1116264 | 0.76 | HTR2A (0.54) | PIK3CGBRAFCLK1CLK2CLK4 | |
| SCHEMBL1116262 | 0.76 | HTR2A (0.54) | PIK3CGBRAFCLK1CLK2CLK4 | |
| SCHEMBL1116040 | 0.75 | HTR2A (0.51) | PIK3CGGSK3AGSK3BCLK1CLK2 | |
| SCHEMBL1116037 | 0.75 | HTR2A (0.51) | PIK3CGGSK3AGSK3BCLK1CLK2 | |
| SCHEMBL1228305 | 0.75 | BRAF (0.60) | PIK3CGBRAFGSK3AGSK3BMAPT | |
| SCHEMBL1228309 | 0.75 | BRAF (0.60) | PIK3CGBRAFGSK3AGSK3BMAPT | |
| SCHEMBL6858409 | 0.74 | GSK3A (0.41) | DYRK2DYRK1APIM1DYRK3CSNK2A2 | |
| SCHEMBL1116169 | 0.72 | CA2 (0.42) | DYRK2DYRK1APIM1DYRK3CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011015646-A2 | FURAN-IMIDAZOLONE DERIVATIVES, FOR THE TREATMENT OF COGNITIVE, NEURODEGENERATIVE OR NEURONAL DISEASES OR DISORDERS | NOSCIRA, S.A. (ES) | 2011-02-10 | — | — | WO | disclosed |
| EP-2281824-A1 | Furan-imidazolone derivatives, for the treatment of cognitive, neurodegenerative or neuronal diseases or disorders | NOSCIRA, S.A. (ES) | 2011-02-09 | — | — | EP | disclosed |