Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | XBP1 | P17861 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 3/20 | 0.42 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11170798 | 0.97 | KDM4E (0.46) | KDM4ETSHRHTTTP53XBP1 | |
| Potassium Ion SCHEMBL10961555 | 0.97 | KDM4E (0.46) | KDM4ETSHRHTTTP53XBP1 | |
| Water SCHEMBL10963375 | 0.96 | KDM4E (0.45) | KDM4ETSHRHTTTP53XBP1 | |
| SCHEMBL10961560 | 0.87 | KDM4E (0.48) | KDM4ETSHRHTTTP53XBP1 | |
| SCHEMBL11155201 | 0.80 | TSHR (0.49) | KDM4ETSHRHTTTP53XBP1 | |
| Lithium Ion SCHEMBL11164279 | 0.78 | KDM4E (0.43) | KDM4ETSHRHTTTP53XBP1 | |
| SCHEMBL11163717 | 0.75 | MAPT (0.61) | KDM4ETSHRHTTTP53XBP1 | |
| Potassium Ion SCHEMBL10961551 | 0.75 | KDM4E (0.43) | KDM4ETSHRHTTTP53XBP1 | |
| SCHEMBL11170785 | 0.75 | KDM4E (0.43) | KDM4ETSHRHTTTP53XBP1 | |
| SCHEMBL10964940 | 0.75 | HSD17B10 (0.53) | KDM4ETSHRMAPTATMHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4400508-A | AGRICULTURE; PLANT DISEASES; ANTISEPTICS | UBE INDUSTRIES, LTD. (JP) | 1983-08-23 | — | — | US | claimed |
| EP-0052341-A1 | Orotic acid derivatives and their use as agricultural chemicals | UBE INDUSTRIES, LTD. (JP) | 1982-05-26 | — | — | EP | claimed |