Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | RECQL | P46063 | 1/20 | 0.63 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | AKT1 | P31749 | 1/20 | 0.52 |
| ▸ | CNKSR1 | Q969H4 | 1/20 | 0.52 |
| ▸ | SLC6A4 | P31645 | 7/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | HTR2A | P28223 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11162987 | 0.88 | AKR1B1 (0.74) | ALDH1A1RECQLAKR1B1CYP1A2CYP2C9 | |
| SCHEMBL11170511 | 0.88 | ALDH1A1 (0.67) | ALDH1A1RECQLAKR1B1CYP1A2CYP2C9 | |
| SCHEMBL11160326 | 0.86 | AKR1B1 (0.77) | AKR1B1CYP1A2CYP2C9MEN1KMT2A | |
| SCHEMBL9215996 | 0.81 | AKR1B1 (0.69) | ALDH1A1RECQLAKR1B1CYP1A2CYP2C9 | |
| SCHEMBL9210985 | 0.80 | ALDH1A1 (0.67) | ALDH1A1RECQLAKR1B1CYP1A2CYP2C9 | |
| SCHEMBL9217271 | 0.80 | ALDH1A1 (0.67) | ALDH1A1RECQLAKR1B1CYP1A2CYP2C9 | |
| SCHEMBL9277880 | 0.79 | ALDH1A1 (0.62) | ALDH1A1RECQLAKR1B1CYP1A2CYP2C9 | |
| SCHEMBL9207026 | 0.78 | ALDH1A1 (0.67) | ALDH1A1RECQLAKR1B1CYP1A2CYP2C9 | |
| SCHEMBL11158759 | 0.78 | AKR1B1 (0.60) | ALDH1A1RECQLAKR1B1CYP1A2CYP2C9 | |
| SCHEMBL11165597 | 0.78 | AKR1B1 (0.77) | ALDH1A1RECQLAKR1B1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4393062-A | ALDOSE REDUCTASE INHIBITOR | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1983-07-12 | — | — | US | disclosed |
| EP-0002895-B1 | ENZYME INHIBITORY PHTHALAZIN-4-YLACETIC ACID DERIVATIVES, PHARMACEUTICAL COMPOSITIONS THEREOF, AND PROCESS FOR THEIR MANUFACTURE | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1981-10-14 | — | — | EP | disclosed |
| US-4251528-A | ALDOSE REDUCTASE INHIBITORS USEFUL IN DIABETES, GALACTOSEMIA | IMPERIAL CHEMICAL INDUSTRIES LIMITED (GB) | 1981-02-17 | — | — | US | disclosed |
| EP-0002895-A1 | Enzyme inhibitory phthalazin-4-ylacetic acid derivatives, pharmaceutical compositions thereof, and process for their manufacture | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1979-07-11 | — | — | EP | disclosed |