SCHEMBL11168232

SCHEMBL11168232

N#CC=C(N)c1cccs1

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RECQL P46063 1/20 0.43
CES2 O00748 1/20 0.42
CES1 P23141 1/20 0.42
DAO P14920 1/20 0.41
NOS1 P29475 1/20 0.41
NPC1 O15118 3/20 0.38
RAB9A P51151 3/20 0.38
KMT2A Q03164 2/20 0.38
ALDH1A1 P00352 2/20 0.38
MEN1 O00255 1/20 0.38
LMNA P02545 1/20 0.38
POLB P06746 1/20 0.38
HDAC1 Q13547 1/20 0.38
HPGD P15428 2/20 0.37
KDM4E B2RXH2 1/20 0.37
TP53 P04637 1/20 0.37
GAA P10253 1/20 0.37
MAPT P10636 1/20 0.37
NFKB1 P19838 1/20 0.37
NFKB2 Q00653 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11168229 1.00 RECQL (0.43) RECQLCES2CES1DAONOS1
SCHEMBL4709469 0.81 CES2 (0.47) CES2CES1DAONOS1NPC1
SCHEMBL22733818 0.80 CES2 (0.45) CES2CES1DAONOS1NPC1
SCHEMBL12849961 0.77
SCHEMBL29906357 0.77 CES2 (0.42) CES2CES1DAONPC1RAB9A
SCHEMBL1172994 0.77 CES2 (0.42) CES2CES1DAONPC1RAB9A
SCHEMBL18010217 0.76 CES2 (0.41) CES2CES1DAONPC1RAB9A
SCHEMBL4158262 0.72 RECQL (0.50) RECQLCES2CES1DAONPC1
SCHEMBL4158261 0.72 RECQL (0.50) RECQLCES2CES1DAONPC1
SCHEMBL4158257 0.72 RECQL (0.50) RECQLCES2CES1DAONPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4390545-A FENBUFEN AND B-OXO (OR) IMINO THIOPHENEPROPIONITRILES AMERICAN CYANAMID COMPANY (US) 1983-06-28 US claimed
US-4241077-A ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS AMERICAN CYANAMID COMPANY (US) 1980-12-23 US claimed
US-4189436-A ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS AMERICAN CYANAMID COMPANY (US) 1980-02-19 US claimed
US-4390545-A FENBUFEN AND B-OXO (OR) IMINO THIOPHENEPROPIONITRILES AMERICAN CYANAMID COMPANY (US) 1983-06-28 US disclosed
US-4350689-A Combinations of agents which give enhanced anti-inflammatory activity AMERICAN CYANAMID COMPANY (US) 1982-09-21 US disclosed
US-4325949-A ACETOXYBENZOIC ACID/O- AMERICAN CYANAMID COMPANY (US) 1982-04-20 US disclosed
EP-0034270-A1 Combinations of agents which give enhanced anti-inflammatory activity AMERICAN CYANAMID COMPANY (US) 1981-08-26 EP disclosed
US-4241077-A ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS AMERICAN CYANAMID COMPANY (US) 1980-12-23 US disclosed
US-4241077-A ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS AMERICAN CYANAMID COMPANY (US) 1980-12-23 US disclosed
US-4189436-A ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS AMERICAN CYANAMID COMPANY (US) 1980-02-19 US disclosed
US-4189436-A ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS AMERICAN CYANAMID COMPANY (US) 1980-02-19 US disclosed