Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD1 | P21728 | 3/20 | 0.38 |
| ▸ | DRD5 | P21918 | 3/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | DRD3 | P35462 | 2/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | DRD4 | P21917 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.37 |
| ▸ | NPY2R | P49146 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL11169441 | 0.89 | SMN1; SMN2 (0.41) | DRD1DRD5DRD2TDP1MAPT | |
| Fumaric Acid SCHEMBL11169435 | 0.89 | SMN1; SMN2 (0.41) | DRD1DRD5DRD2TDP1MAPT | |
| SCHEMBL11160967 | 0.87 | DRD1 (0.47) | DRD1DRD5DRD2DRD3TDP1 | |
| Fumaric Acid SCHEMBL11169294 | 0.86 | MEN1 (0.43) | DRD1DRD5DRD2DRD3TDP1 | |
| Fumaric Acid SCHEMBL11169280 | 0.86 | MEN1 (0.43) | DRD1DRD5DRD2DRD3TDP1 | |
| SCHEMBL11171087 | 0.83 | TDP1 (0.35) | DRD1DRD2TDP1MEN1KMT2A | |
| SCHEMBL11160737 | 0.82 | DRD1 (0.43) | DRD1DRD5DRD2DRD3MAPT | |
| SCHEMBL11155684 | 0.80 | DRD2 (0.41) | DRD1DRD5DRD2DRD3MAPT | |
| SCHEMBL11169221 | 0.78 | MEN1 (0.39) | TDP1DRD4MEN1KMT2ALMNA | |
| SCHEMBL11160646 | 0.78 | GAA (0.47) | MAPTKDM4EMEN1ALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0007070-B1 | 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES, PROCESS FOR THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS HAVING DOPAMINE RECEPTOR BLOCKING ACTIVITY | SMITHKLINE BECKMAN CORPORATION (US) | 1983-01-19 | — | — | EP | disclosed |
| US-4265890-A | ANTIPSYCHOTIC, ANTIEMETICS | SMITHKLINE CORPORATION (US) | 1981-05-05 | — | — | US | disclosed |