Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.74 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.59 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11188991 | 0.98 | MAPK14 (0.72) | MAPK14PTGS1PTGS2MAPK13MAPK12 | |
| SCHEMBL11176876 | 0.97 | MAPK14 (0.74) | MAPK14PTGS1PTGS2MAPK13MAPK12 | |
| Bromide SCHEMBL11207541 | 0.95 | MAPK14 (0.72) | MAPK14PTGS1PTGS2MAPK13MAPK12 | |
| SCHEMBL10373989 | 0.94 | MAPK14 (0.72) | MAPK14PTGS1PTGS2MAPK13MAPK12 | |
| Bromide SCHEMBL11187122 | 0.92 | MAPK14 (0.71) | MAPK14PTGS1PTGS2MAPK13MAPK12 | |
| SCHEMBL10963620 | 0.88 | MAPK14 (0.87) | MAPK14PTGS1PTGS2MAPK13MAPK12 | |
| SCHEMBL11178195 | 0.87 | MAPK14 (0.64) | MAPK14PTGS1PTGS2MAPK13MAPK12 | |
| SCHEMBL9215059 | 0.84 | KDM4E (0.64) | — | |
| SCHEMBL9211133 | 0.83 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL8125187 | 0.82 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0010361-B1 | BIS-IMIDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1983-04-27 | — | — | EP | disclosed |
| EP-0010361-A1 | Bis-imidazoles, their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1980-04-30 | — | — | EP | disclosed |
| US-4188397-A | ANTIARTHRITIC, ANTIINFLAMMATORY | SMITHKLINE CORPORATION (US) | 1980-02-12 | — | — | US | disclosed |