SCHEMBL1117827

SCHEMBL1117827

CC(C)(C)[Si](OCC1CCCCO1)(c1ccccc1)c1ccccc1

nearest known ligand 0.48

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MGLL Q99685 3/20 0.41
PLK1 P53350 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10175324 1.00 MGLL (0.41) MGLLPLK1
SCHEMBL10175323 1.00 MGLL (0.41) MGLLPLK1
SCHEMBL8825516 0.96 POLB (0.40)
SCHEMBL8825520 0.96 POLB (0.40)
SCHEMBL28346561 0.92 SMYD2 (0.40)
SCHEMBL30563746 0.88 SMYD2 (0.36) MGLL
SCHEMBL9886817 0.83 MEN1 (0.47) MGLL
SCHEMBL20500291 0.83 MEN1 (0.47) MGLL
SCHEMBL7203588 0.83 MEN1 (0.47) MGLL
SCHEMBL1564475 0.83 SMYD2 (0.39) PLK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023165570-A1 CYCLOALKYL OR HETEROCYCLYL SUBSTITUTED HETEROARYL COMPOUND, AND COMPOSITION AND USE THEREOF 深圳市塔吉瑞生物医药有限公司 2023-09-07 WO disclosed
EP-2280981-A1 BRIDGED HETEROCYCLES AS HIV INTEGRASE INHIBITORS Bristol-Myers Squibb Company (US) 2011-02-09 EP disclosed
WO-2009117540-A1 BRIDGED HETEROCYCLES AS HIV INTEGRASE INHIBITORS BRISTOL-MYERS SQUIBB COMPANY (US) 2009-09-24 WO disclosed