Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.55 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11190335 | 0.98 | MAPK14 (0.56) | MAPK14MAPK13RAF1MAPK12MAPK11 | |
| SCHEMBL11172466 | 0.84 | MAPK14 (0.57) | MAPK14MAPK13RAF1MAPK12MAPK11 | |
| SCHEMBL5434841 | 0.84 | MAPK14 (0.56) | MAPK14 | |
| Bromide SCHEMBL11187122 | 0.83 | MAPK14 (0.71) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5434845 | 0.82 | MAPK14 (0.49) | MAPK14 | |
| SCHEMBL10373989 | 0.81 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11 | |
| Bromide SCHEMBL11178852 | 0.80 | MAPK14 (0.52) | MAPK14MAPK13MAPK12MAPK11 | |
| Bromide SCHEMBL11178458 | 0.80 | PTGS1 (0.60) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL5452003 | 0.79 | PTGES (0.53) | — | |
| SCHEMBL5440675 | 0.79 | MAPK14 (0.53) | MAPK14MAPK13RAF1MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0010361-B1 | BIS-IMIDAZOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SMITHKLINE BECKMAN CORPORATION (US) | 1983-04-27 | — | — | EP | disclosed |
| EP-0010361-A1 | Bis-imidazoles, their preparation and pharmaceutical compositions containing them | SMITHKLINE BECKMAN CORPORATION (US) | 1980-04-30 | — | — | EP | disclosed |
| US-4188397-A | ANTIARTHRITIC, ANTIINFLAMMATORY | SMITHKLINE CORPORATION (US) | 1980-02-12 | — | — | US | disclosed |