Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | PDE4A | P27815 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | CXCR4 | P61073 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.30 |
| ▸ | CA1 | P00915 | 1/20 | 0.30 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | CA9 | Q16790 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29001721 | 0.92 | HIF1A (0.46) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL7052608 | 0.87 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL28470549 | 0.87 | HIF1A (0.50) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL3824518 | 0.87 | — | — | |
| SCHEMBL238766 | 0.87 | HIF1A (0.39) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL2356063 | 0.82 | HIF1A (0.42) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperazine SCHEMBL28198825 | 0.81 | CXCR4 (0.44) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Hydrochloric Acid SCHEMBL28856596 | 0.78 | ALDH1A1 (0.39) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Ethylene SCHEMBL28380221 | 0.75 | HIF1A (0.36) | HIF1AMAPTPDE4AKDRSMN1; SMN2 | |
| SCHEMBL7052601 | 0.74 | HIF1A (1.00) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4375505-A | Fuser member | EASTMAN KODAK COMPANY (US) | 1983-03-01 | — | — | US | disclosed |
| US-4199626-A | Electrographic fixing member and apparatus and process using same | EASTMAN KODAK COMPANY (US) | 1980-04-22 | — | — | US | disclosed |