Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.52 |
| ▸ | RAB9A | P51151 | 2/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | TPH1 | P17752 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11008739 | 0.78 | HSD17B10 (0.83) | NPC1RAB9AHSD17B10TSHRLMNA | |
| SCHEMBL10356773 | 0.78 | MCHR1 (0.55) | HSD17B10TSHRLMNAMAPTMCHR1 | |
| SCHEMBL11165965 | 0.78 | MCHR1 (0.55) | HSD17B10TSHRLMNAMAPTMCHR1 | |
| SCHEMBL11196583 | 0.78 | MCHR1 (0.53) | NPC1RAB9AHSD17B10TSHRLMNA | |
| SCHEMBL11165531 | 0.78 | MCHR1 (0.55) | HSD17B10TSHRLMNAMAPTMCHR1 | |
| SCHEMBL11178712 | 0.77 | POLB (0.55) | HSD17B10TSHRMAPTMCHR1CYP2D6 | |
| SCHEMBL11180926 | 0.77 | NPC1 (0.56) | NPC1RAB9ALMNAMAPTCYP2D6 | |
| SCHEMBL11441498 | 0.77 | MCHR1 (0.56) | NPC1RAB9ALMNAMAPTMCHR1 | |
| SCHEMBL11305181 | 0.76 | TSHR (0.50) | NPC1RAB9AHSD17B10TSHRLMNA | |
| SCHEMBL11304640 | 0.76 | HSD17B10 (0.57) | RAB9AHSD17B10TSHRLMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0023569-B1 | DERIVATIVES OF CARBOXYLIC ACIDS, THEIR PREPARATION AND MEDICAMENTS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1983-06-22 | — | — | EP | disclosed |
| EP-0023569-A1 | Derivatives of carboxylic acids, their preparation and medicaments containing them | Dr. Karl Thomae GmbH (DE) | 1981-02-11 | — | — | EP | disclosed |