Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 14/20 | 0.50 |
| ▸ | IDH1 | O75874 | 2/20 | 0.38 |
| ▸ | FKBP1A | P62942 | 2/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL75919 | 0.74 | HSD11B1 (0.50) | HSD11B1IDH1EPHX2 | |
| SCHEMBL704559 | 0.73 | HSD11B1 (0.49) | HSD11B1 | |
| SCHEMBL703444 | 0.72 | HSD11B1 (0.48) | HSD11B1 | |
| SCHEMBL3428074 | 0.67 | HSD11B1 (1.00) | HSD11B1 | |
| SCHEMBL703064 | 0.67 | HSD11B1 (0.53) | HSD11B1 | |
| SCHEMBL703065 | 0.67 | HSD11B1 (0.53) | HSD11B1 | |
| SCHEMBL703069 | 0.67 | HSD11B1 (0.51) | HSD11B1IDH1EPHX2 | |
| SCHEMBL702971 | 0.66 | HSD11B1 (0.51) | HSD11B1 | |
| SCHEMBL704402 | 0.66 | HSD11B1 (0.51) | HSD11B1 | |
| SCHEMBL702970 | 0.66 | HSD11B1 (0.51) | HSD11B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2280970-A1 | IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2011-02-09 | — | — | EP | disclosed |
| WO-2009132986-A1 | IMIDAZOLIDINONE DERIVATIVES AS 11B-HSD1 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-11-05 | — | — | WO | disclosed |