Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 0.98 |
| ▸ | ESR2 | Q92731 | 13/20 | 0.98 |
| ▸ | LTA4H | P09960 | 1/20 | 0.57 |
| ▸ | EBP | Q15125 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.53 |
| ▸ | PSMB1 | P20618 | 1/20 | 0.52 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.52 |
| ▸ | PSMB2 | P49721 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11188187 | 0.94 | ESR1 (0.98) | ESR1ESR2EBPSIGMAR1PSMB1 | |
| SCHEMBL7111413 | 0.94 | ESR1 (0.86) | ESR1ESR2LTA4HMCHR1PSMB1 | |
| SCHEMBL7108582 | 0.93 | ESR1 (0.88) | ESR1ESR2EBPSIGMAR1PSMB1 | |
| SCHEMBL14078413 | 0.90 | ESR1 (0.90) | ESR1ESR2EBPSIGMAR1PSMB1 | |
| SCHEMBL3870779 | 0.90 | ESR1 (0.80) | ESR1ESR2LTA4HEBPSIGMAR1 | |
| SCHEMBL4660156 | 0.89 | ESR1 (0.79) | ESR1ESR2LTA4HEBPSIGMAR1 | |
| SCHEMBL11185809 | 0.89 | ESR1 (0.82) | ESR1ESR2LTA4HEBPSIGMAR1 | |
| SCHEMBL11184215 | 0.89 | ESR1 (0.79) | ESR1ESR2LTA4HEBPSIGMAR1 | |
| SCHEMBL3870510 | 0.89 | ESR1 (0.82) | ESR1ESR2LTA4HEBPSIGMAR1 | |
| SCHEMBL7111304 | 0.89 | ESR1 (0.82) | ESR1ESR2LTA4HMCHR1PSMB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4400543-A | ANTIFERTILITY AGENTS | ELI LILLY AND COMPANY (US) | 1983-08-23 | — | — | US | disclosed |
| US-4323707-A | USEFUL FOR AMIMALS, AROYL-PHENYL-NAPHTHALENES OR DIHYDRONAPHTHALENES | ELI LILLY AND COMPANY (US) | 1982-04-06 | — | — | US | disclosed |
| US-4230862-A | 3-PHENYL-4-AROYL-1,2-DIHYDRONAPHTHALENES AND 1-ARYOYL-2-PHENYLNAPHTHALENES | ELI LILLY AND COMPANY (US) | 1980-10-28 | — | — | US | disclosed |