SCHEMBL4660156

SCHEMBL4660156

O=C(C1=C(c2ccccc2)CCc2ccccc21)c1ccc(OCCN2CCCC2)cc1

nearest known ligand 0.79

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 4/20 0.79
ESR2 Q92731 4/20 0.79
LTA4H P09960 2/20 0.63
MCHR1 Q99705 1/20 0.57
PSMB1 P20618 2/20 0.57
PSMB5 P28074 2/20 0.57
PSMB2 P49721 1/20 0.57
KDM4E B2RXH2 3/20 0.54
HRH4 Q9H3N8 1/20 0.54
EBP Q15125 1/20 0.53
SIGMAR1 Q99720 1/20 0.53
ALDH1A1 P00352 2/20 0.53
HTT P42858 1/20 0.52
GCGR P47871 1/20 0.52
CACNA1B Q00975 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6592276 0.96 ESR1 (0.76) ESR1ESR2LTA4HMCHR1PSMB1
SCHEMBL4651846 0.93 ESR1 (0.81) ESR1ESR2LTA4HMCHR1PSMB1
Trioxifene SCHEMBL29464170 0.92 ESR1 (0.69) ESR1ESR2LTA4HMCHR1PSMB1
SCHEMBL11180048 0.92 ESR1 (0.69) ESR1ESR2LTA4HMCHR1PSMB1
SCHEMBL6595870 0.92 ESR1 (0.83) ESR1ESR2LTA4HMCHR1PSMB1
SCHEMBL11179589 0.92 ESR1 (0.83) ESR1ESR2LTA4HMCHR1PSMB1
Trioxifene SCHEMBL4651963 0.92 ESR1 (0.69) ESR1ESR2LTA4HMCHR1PSMB1
SCHEMBL11176566 0.92 ESR1 (0.69) ESR1ESR2LTA4HMCHR1PSMB1
SCHEMBL4650720 0.91 ESR1 (0.70) ESR1ESR2LTA4HMCHR1PSMB1
Trioxifene SCHEMBL7753024 0.91 ESR1 (0.68) ESR1ESR2LTA4HMCHR1PSMB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 33 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040127440-A1 Methods and compositions for control of bone formation via modulation of neuropeptide Y activity BAYLOR COLLEGE OF MEDICINE 2004-07-01 US claimed
US-20040053864-A1 Methods and compositions for control of bone formation via modulation of neuropeptide y activity BAYLOR COLLEGE OF MEDICINE 2004-03-18 US claimed
EP-2002827-A2 Methods and compositions for control of bone formation via modulation of sympathetic tone THE BAYLOR COLLEGE OF MEDICINE (US) 2008-12-17 EP disclosed
US-20060165683-A1 Methods and compositions for control of bone formation via modulation of sympathetic tone BAYLOR COLLEGE OF MEDICINE 2006-07-27 US disclosed
EP-1542719-A4 METHODS AND COMPOSITIONS FOR CONTROL OF BONE FORMATION VIA MODULATION OF SYMPATHETIC TONE BAYLOR COLLEGE MEDICINE (US) 2006-06-21 EP disclosed
EP-1542719-A2 METHODS AND COMPOSITIONS FOR CONTROL OF BONE FORMATION VIA MODULATION OF SYMPATHETIC TONE THE BAYLOR COLLEGE OF MEDICINE (US) 2005-06-22 EP disclosed
US-20040127440-A1 Methods and compositions for control of bone formation via modulation of neuropeptide Y activity BAYLOR COLLEGE OF MEDICINE 2004-07-01 US disclosed
US-20040053864-A1 Methods and compositions for control of bone formation via modulation of neuropeptide y activity BAYLOR COLLEGE OF MEDICINE 2004-03-18 US disclosed
WO-2003049673-A2 METHODS AND COMPOSITIONS FOR CONTROL OF BONE FORMATION VIA MODULATION OF SYMPATHETIC TONE BAYLOR COLLEGE OF MEDICINE (US) 2003-06-19 WO disclosed
US-6221838-B1 Methods of treating neuropeptide Y-associated conditions ELI LILLY AND COMPANY 2001-04-24 US disclosed
US-6124311-A ADMINISTERING ONCOLYTIC AGENT WITH ENHANCED MULTIDRUG RESISTANCE REVERSING AMOUNT OF SPECIFIED COMPOUND ELI LILLY AND COMPANY (US) 2000-09-26 US disclosed
EP-0709090-A2 Compositions for treating resistant tumors ELI LILLY AND COMPANY (US) 1996-05-01 EP disclosed
WO-1996011677-A1 METHODS FOR TREATING RESISTANT TUMORS ELI LILLY AND COMPANY (US) 1996-04-25 WO disclosed
EP-0707852-A2 Bicyclic bradykinin receptor antagonists ELI LILLY AND COMPANY (US) 1996-04-24 EP disclosed
US-5491140-A ADMINISTERING TO A MAMMAL SUFFERING FROM NERVOUS SYSTEM DISORDERS, RESPIRATORY SYSTEM DISORDERS, UROGENITAL DISORDERS ARTHRITIS, RHEUMATOID, OSTEOPROSIS, PERSISTENT PAIN, MIGRAIN OR POST-OPERATIVE PAIN ELI LILLY AND COMPANY (US) 1996-02-13 US disclosed
WO-1995017095-A1 METHODS FOR THE TREATMENT OR PREVENTION OF CONDITIONS ASSOCIATED WITH AMYLOIDOGENIC REPTIDES ELI LILLY AND COMPANY (US) 1995-06-29 WO disclosed
WO-1995017382-A1 NON-PEPTIDE TACHYKININ RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 1995-06-29 WO disclosed
US-4400543-A ANTIFERTILITY AGENTS ELI LILLY AND COMPANY (US) 1983-08-23 US disclosed
US-4323707-A USEFUL FOR AMIMALS, AROYL-PHENYL-NAPHTHALENES OR DIHYDRONAPHTHALENES ELI LILLY AND COMPANY (US) 1982-04-06 US disclosed
US-4230862-A 3-PHENYL-4-AROYL-1,2-DIHYDRONAPHTHALENES AND 1-ARYOYL-2-PHENYLNAPHTHALENES ELI LILLY AND COMPANY (US) 1980-10-28 US disclosed