Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | RAB9A | P51151 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.58 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.55 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | TGM2 | P21980 | 1/20 | 0.50 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.49 |
| ▸ | UBA2 | Q9UBT2 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7088596 | 0.86 | NPC1 (0.66) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL1420595 | 0.85 | RAB9A (0.59) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL55713 | 0.83 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL8538067 | 0.83 | NPC1 (0.61) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL11524069 | 0.82 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL11524064 | 0.82 | NPC1 (0.49) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL11068449 | 0.81 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL14557553 | 0.81 | NPC1 (0.63) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL11179941 | 0.81 | TSHR (0.52) | MAPTNPY5RALDH1A1MEN1KMT2A | |
| SCHEMBL11180274 | 0.81 | TDP1 (0.52) | NPC1RAB9ASMN1; SMN2TGM2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4293713-A | ANALGESICS, ANTIINFLAMMATORIES, ANTIPYRETICS; PREPARATION FROM ALLOPHANOYL CHLORIDE AND AMINE | TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) | 1981-10-06 | — | — | US | claimed |
| US-4371544-A | ANTIINFLAMMATORY AGENTS, ANALGESTICS | TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) | 1983-02-01 | — | — | US | disclosed |
| US-4293713-A | ANALGESICS, ANTIINFLAMMATORIES, ANTIPYRETICS; PREPARATION FROM ALLOPHANOYL CHLORIDE AND AMINE | TAIHO PHARMACEUTICAL COMPANY LIMITED (JP) | 1981-10-06 | — | — | US | disclosed |
| US-4278672-A | ANALGESICS, ANTIINFLAMMATORY AGENTS | TAIHO PHARMACEUTICAL COMPANY, LIMITED (JP) | 1981-07-14 | — | — | US | disclosed |