Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.49 |
| ▸ | ABCB1 | P08183 | 9/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | HCAR3 | P49019 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GALR2 | O43603 | 1/20 | 0.33 |
| ▸ | MITF | O75030 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | XBP1 | P17861 | 1/20 | 0.33 |
| ▸ | CCR6 | P51684 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Methyl Alcohol SCHEMBL11187636 | 1.00 | KCNH2 (0.49) | KCNH2ABCB1NPSR1MAPTHTT | |
| Methyl Alcohol SCHEMBL11187638 | 1.00 | KCNH2 (0.49) | KCNH2ABCB1NPSR1MAPTHTT | |
| SCHEMBL9550576 | 0.88 | KCNH2 (0.53) | KCNH2NPSR1MAPTHTTKMT2A | |
| SCHEMBL9550572 | 0.88 | KCNH2 (0.53) | KCNH2NPSR1MAPTHTTKMT2A | |
| SCHEMBL9550575 | 0.88 | KCNH2 (0.53) | KCNH2NPSR1MAPTHTTKMT2A | |
| SCHEMBL10886505 | 0.84 | KCNH2 (0.49) | KCNH2NPSR1MAPTHTTKMT2A | |
| SCHEMBL10886491 | 0.84 | KCNH2 (0.49) | KCNH2NPSR1MAPTHTTKMT2A | |
| SCHEMBL10886498 | 0.84 | KCNH2 (0.49) | KCNH2NPSR1MAPTHTTKMT2A | |
| SCHEMBL10730463 | 0.81 | KCNH2 (0.47) | KCNH2NPSR1MAPTHTTKMT2A | |
| SCHEMBL10730470 | 0.81 | KCNH2 (0.47) | KCNH2NPSR1MAPTHTTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0028064-B1 | CHROMANOL DERIVATIVES, A PROCESS FOR THEIR PREPARATION AND A PHARMACEUTICAL COMPOSITION COMPRISING THEM | BEECHAM GROUP PLC (GB) | 1983-07-20 | — | — | EP | disclosed |
| US-4363811-A | Anti-hypertensive chromanol derivatives | BEECHAM GROUP LIMITED (GB) | 1982-12-14 | — | — | US | disclosed |
| EP-0028064-A1 | Chromanol derivatives, a process for their preparation and a pharmaceutical composition comprising them | BEECHAM GROUP PLC (GB) | 1981-05-06 | — | — | EP | disclosed |