Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 7/20 | 0.39 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.39 |
| ▸ | PPARD | Q03181 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | HRH2 | P25021 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 7/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11181517 | 0.90 | MAPT (0.44) | SMN1; SMN2LMNAPOLBNPC1MAPT | |
| SCHEMBL11189087 | 0.90 | MAPT (0.48) | SMN1; SMN2LMNANPC1MAPTKDM4E | |
| SCHEMBL11176051 | 0.88 | MAPT (0.47) | SMN1; SMN2LMNANPC1MAPTKDM4E | |
| SCHEMBL11181130 | 0.87 | MAPT (0.46) | SMN1; SMN2LMNATSHRNPC1MAPT | |
| SCHEMBL11179891 | 0.87 | MAPT (0.46) | SMN1; SMN2LMNATSHRNPC1MAPT | |
| SCHEMBL11184440 | 0.87 | MAPT (0.46) | SMN1; SMN2LMNATSHRNPC1MAPT | |
| SCHEMBL11184224 | 0.87 | HRH2 (0.51) | NPC1MAPTHRH2HRH3MEN1 | |
| SCHEMBL11184726 | 0.86 | NPC1 (0.39) | SMN1; SMN2NPC1MAPTKDM4EPPARD | |
| SCHEMBL11184666 | 0.85 | CDK5 (0.39) | LMNANPC1MAPTKDM4EPPARD | |
| SCHEMBL11183521 | 0.84 | LMNA (0.39) | SMN1; SMN2LMNAPOLBNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4402849-A | DIELECTRICS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1983-09-06 | — | — | US | disclosed |
| EP-0031021-B1 | TETRAHYDROQUINAZOLINES, PROCESS FOR THEIR PREPARATION, LIQUID CRYSTALLINE DIELECTRICS CONTAINING THEM AND ELECTRO-OPTICAL DISPLAY ELEMENT | MERCK PATENT GmbH (DE) | 1983-05-18 | — | — | EP | disclosed |
| EP-0031021-A1 | Tetrahydroquinazolines, process for their preparation, liquid crystalline dielectrics containing them and electro-optical display element | MERCK PATENT GmbH (DE) | 1981-07-01 | — | — | EP | disclosed |